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Treasure T, Pepper J. Personalised External Aortic Root Support (PEARS) Compared with Alternatives for People with Life-Threatening Genetically Determined Aneurysms of the Aortic Root. Diseases. 2015;3(1):2-14doi: 10.3390/diseases3010002.
Treasure, T., & Pepper, J. (2015). Personalised External Aortic Root Support (PEARS) Compared with Alternatives for People with Life-Threatening Genetically Determined Aneurysms of the Aortic Root. Diseases (Basel, Switzerland), 3(1), 2-14. https://doi.org/10.3390/diseases3010002
Treasure, Tom, and Pepper, John. "Personalised External Aortic Root Support (PEARS) Compared with Alternatives for People with Life-Threatening Genetically Determined Aneurysms of the Aortic Root." Diseases (Basel, Switzerland) vol. 3,1 (2015): 2-14. doi: https://doi.org/10.3390/diseases3010002
Treasure T, Pepper J. Personalised External Aortic Root Support (PEARS) Compared with Alternatives for People with Life-Threatening Genetically Determined Aneurysms of the Aortic Root. Diseases. 2015 Jan 15;3(1):2-14. doi: 10.3390/diseases3010002. PMID: 28943604; PMCID: PMC5548228.
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Diseases. 2015 Jan 15;3(1):2-14. doi: 10.3390/diseases3010002.

Personalised External Aortic Root Support (PEARS) Compared with Alternatives for People with Life-Threatening Genetically Determined Aneurysms of the Aortic Root.

Diseases (Basel, Switzerland)

Tom Treasure, John Pepper

Affiliations

  1. Clinical Operational Research Unit, Department of Mathematics, University College London, Gower Street, London WC1E 6BT, UK. [email protected].
  2. National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Unit (BRU), Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK.

PMID: 28943604 PMCID: PMC5548228 DOI: 10.3390/diseases3010002

Abstract

Personalised external aortic support was first proposed in 2000 by Tal Golesworthy, an engineer with familial Marfan syndrome and an aortic root aneurysm. After putting together a research and development team, and finding a surgeon to take on the challenge to join him in this innovative approach, he was central to the manufacture of the device, custom made for his own aorta. He was the patient for the 'first in man' operation in 2004. Ten years later he is well and 45 other people have had their own personalised device implanted. In this account, the stepwise record of proof of principle, comparative quantification of the surgical and perioperative requirements, 10 years of results, and development and research plans for the future are presented.

Keywords: Marfan syndrome; aortic root aneurysm; surgery

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