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Georgiev YN, Paulsen BS, Kiyohara H, et al. Tilia tomentosa pectins exhibit dual mode of action on phagocytes as β-glucuronic acid monomers are abundant in their rhamnogalacturonans I. Carbohydr Polym. 2017;175:178-191doi: 10.1016/j.carbpol.2017.07.073.
Georgiev, Y. N., Paulsen, B. S., Kiyohara, H., Ciz, M., Ognyanov, M. H., Vasicek, O., Rise, F., Denev, P. N., Lojek, A., Batsalova, T. G., Dzhambazov, B. M., Yamada, H., Lund, R., Barsett, H., Krastanov, A. I., Yanakieva, I. Z., & Kratchanova, M. G. (2017). Tilia tomentosa pectins exhibit dual mode of action on phagocytes as β-glucuronic acid monomers are abundant in their rhamnogalacturonans I. Carbohydrate polymers, 175178-191. https://doi.org/10.1016/j.carbpol.2017.07.073
Georgiev, Yordan N, et al. "Tilia tomentosa pectins exhibit dual mode of action on phagocytes as β-glucuronic acid monomers are abundant in their rhamnogalacturonans I." Carbohydrate polymers vol. 175 (2017): 178-191. doi: https://doi.org/10.1016/j.carbpol.2017.07.073
Georgiev YN, Paulsen BS, Kiyohara H, Ciz M, Ognyanov MH, Vasicek O, Rise F, Denev PN, Lojek A, Batsalova TG, Dzhambazov BM, Yamada H, Lund R, Barsett H, Krastanov AI, Yanakieva IZ, Kratchanova MG. Tilia tomentosa pectins exhibit dual mode of action on phagocytes as β-glucuronic acid monomers are abundant in their rhamnogalacturonans I. Carbohydr Polym. 2017 Nov 01;175:178-191. doi: 10.1016/j.carbpol.2017.07.073. Epub 2017 Jul 25. PMID: 28917854.
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Carbohydr Polym. 2017 Nov 01;175:178-191. doi: 10.1016/j.carbpol.2017.07.073. Epub 2017 Jul 25.

Tilia tomentosa pectins exhibit dual mode of action on phagocytes as β-glucuronic acid monomers are abundant in their rhamnogalacturonans I.

Carbohydrate polymers

Yordan N Georgiev, Berit S Paulsen, Hiroaki Kiyohara, Milan Ciz, Manol H Ognyanov, Ondrej Vasicek, Frode Rise, Petko N Denev, Antonin Lojek, Tsvetelina G Batsalova, Balik M Dzhambazov, Haruki Yamada, Reidar Lund, Hilde Barsett, Albert I Krastanov, Irina Z Yanakieva, Maria G Kratchanova

Affiliations

  1. Laboratory of Biologically Active Substances, Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 139 Ruski Blvd., BG-4000, Plovdiv, Bulgaria; Innovative-Technological Center Ltd., 20 Dr. G. M. Dimitrov Str., BG-4000, Plovdiv, Bulgaria.
  2. Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, NO-0316, Oslo, Norway.
  3. Department of Drug Discovery Science, Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, JP-108-8641, Tokyo, Japan.
  4. Department of Free Radical Pathophysiology, Institute of Biophysics, Czech Academy of Sciences, 135 Kralovopolska, CZ-612 65, Brno, Czech Republic.
  5. Department of Free Radical Pathophysiology, Institute of Biophysics, Czech Academy of Sciences, 135 Kralovopolska, CZ-612 65, Brno, Czech Republic; International Clinical Research Center - Center of Biomolecular and Cellular Engineering, St. Anne's University Hospital Brno, 53 Pekarska, CZ-656 91, Brno, Czech Republic.
  6. Department of Chemistry, University of Oslo, P.O. Box 1033 Blindern, NO-0315, Oslo, Norway.
  7. Department of Developmental Biology, Plovdiv University Paisii Hilendarski, 24 Tsar Assen Str., BG-4000, Plovdiv, Bulgaria.
  8. Department of Biotechnology, University of Food Technologies, 26 Maritza Blvd., BG-4002, Plovdiv, Bulgaria.
  9. Laboratory of Biologically Active Substances, Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 139 Ruski Blvd., BG-4000, Plovdiv, Bulgaria; Innovative-Technological Center Ltd., 20 Dr. G. M. Dimitrov Str., BG-4000, Plovdiv, Bulgaria. Electronic address: [email protected].

PMID: 28917854 DOI: 10.1016/j.carbpol.2017.07.073

Abstract

Silver linden flowers contain different pectins (PSI-PSIII) with immunomodulating properties. PSI is a low-esterified pectic polysaccharide with predominant homogalacturonan region, followed by rhamnogalacturonan I (RGI) with arabinogalactan II and RGII (traces) domains. PSII and PSIII are unusual glucuronidated RGI polymers. PSIII is a unique high molecular weight RGI, having almost completely O-3 glucuronidated GalA units with >30% O-3 acetylation at the Rha units. Linden pectins induced reactive oxygen species (ROS) and NO generation from non-stimulated whole blood phagocytes and macrophages, resp., but suppressed OZP-(opsonized zymosan particles)-activated ROS generation, LPS-induced iNOS expression and NO production. This dual mode of action suggests their anti-inflammatory activity, which is known for silver linden extracts. PSI expressed the highest complement fixation and macrophage-stimulating activities and was active on intestinal Peyer's patch cells. PSIII was active on non-stimulated neutrophils, as it induced ß

Copyright © 2017 Elsevier Ltd. All rights reserved.

Keywords: Anti-inflammatory activity; Immunomodulating polysaccharides; Neutrophils; Pectin; Peyer’s patches; Tilia flowers

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