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Gomes CPC, Spencer H, Ford KL, et al. The Function and Therapeutic Potential of Long Non-coding RNAs in Cardiovascular Development and Disease. Mol Ther Nucleic Acids. 2017;8:494-507doi: 10.1016/j.omtn.2017.07.014.
Gomes, C. P. C., Spencer, H., Ford, K. L., Michel, L. Y. M., Baker, A. H., Emanueli, C., Balligand, J. L., Devaux, Y. (2017). The Function and Therapeutic Potential of Long Non-coding RNAs in Cardiovascular Development and Disease. Molecular therapy. Nucleic acids, 8494-507. https://doi.org/10.1016/j.omtn.2017.07.014
Gomes, Clarissa P C, et al. "The Function and Therapeutic Potential of Long Non-coding RNAs in Cardiovascular Development and Disease." Molecular therapy. Nucleic acids vol. 8 (2017): 494-507. doi: https://doi.org/10.1016/j.omtn.2017.07.014
Gomes CPC, Spencer H, Ford KL, Michel LYM, Baker AH, Emanueli C, Balligand JL, Devaux Y. The Function and Therapeutic Potential of Long Non-coding RNAs in Cardiovascular Development and Disease. Mol Ther Nucleic Acids. 2017 Sep 15;8:494-507. doi: 10.1016/j.omtn.2017.07.014. Epub 2017 Jul 28. PMID: 28918050; PMCID: PMC5565632.
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Mol Ther Nucleic Acids. 2017 Sep 15;8:494-507. doi: 10.1016/j.omtn.2017.07.014. Epub 2017 Jul 28.

The Function and Therapeutic Potential of Long Non-coding RNAs in Cardiovascular Development and Disease.

Molecular therapy. Nucleic acids

Clarissa P C Gomes, Helen Spencer, Kerrie L Ford, Lauriane Y M Michel, Andrew H Baker, Costanza Emanueli, Jean-Luc Balligand, Yvan Devaux,

Affiliations

  1. Cardiovascular Research Unit, Luxembourg Institute of Health, 1526 Luxembourg, Luxembourg.
  2. Centre for Cardiovascular Science, University of Edinburgh, Edinburgh EH8 9YL, UK.
  3. Bristol Heart Institute, University of Bristol, Bristol BS8 1TH, UK.
  4. Unité de Pharmacologie et de Thérapeutique, Institut de Recherche Experimentale et Clinique, Université Catholique de Louvain, 1348 Louvain-la-Neuve, Belgium.
  5. Bristol Heart Institute, University of Bristol, Bristol BS8 1TH, UK; National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.
  6. Cardiovascular Research Unit, Luxembourg Institute of Health, 1526 Luxembourg, Luxembourg. Electronic address: [email protected].

PMID: 28918050 PMCID: PMC5565632 DOI: 10.1016/j.omtn.2017.07.014

Abstract

The popularization of genome-wide analyses and RNA sequencing led to the discovery that a large part of the human genome, while effectively transcribed, does not encode proteins. Long non-coding RNAs have emerged as critical regulators of gene expression in both normal and disease states. Studies of long non-coding RNAs expressed in the heart, in combination with gene association studies, revealed that these molecules are regulated during cardiovascular development and disease. Some long non-coding RNAs have been functionally implicated in cardiac pathophysiology and constitute potential therapeutic targets. Here, we review the current knowledge of the function of long non-coding RNAs in the cardiovascular system, with an emphasis on cardiovascular development and biology, focusing on hypertension, coronary artery disease, myocardial infarction, ischemia, and heart failure. We discuss potential therapeutic implications and the challenges of long non-coding RNA research, with directions for future research and translational focus.

Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

Keywords: RNAs; cardiovascular development; cardiovascular disease; cardiovascular system; long non-coding RNAs; non-coding RNAs; therapy; transcriptomics; vascular disease

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