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Sawayama H, Yoshida N, Miyamoto Y, et al. Primary colonic well-differentiated / dedifferentiated liposarcoma of the ascending colon: a case report. Surg Case Rep. 2017;3(1):96doi: 10.1186/s40792-017-0373-4.
Sawayama, H., Yoshida, N., Miyamoto, Y., Uchihara, T., Toihata, T., Yagi, T., Hiyoshi, Y., Iwatsuki, M., Baba, Y., & Baba, H. (2017). Primary colonic well-differentiated / dedifferentiated liposarcoma of the ascending colon: a case report. Surgical case reports, 3(1), 96. https://doi.org/10.1186/s40792-017-0373-4
Sawayama, Hiroshi, et al. "Primary colonic well-differentiated / dedifferentiated liposarcoma of the ascending colon: a case report." Surgical case reports vol. 3,1 (2017): 96. doi: https://doi.org/10.1186/s40792-017-0373-4
Sawayama H, Yoshida N, Miyamoto Y, Uchihara T, Toihata T, Yagi T, Hiyoshi Y, Iwatsuki M, Baba Y, Baba H. Primary colonic well-differentiated / dedifferentiated liposarcoma of the ascending colon: a case report. Surg Case Rep. 2017 Aug 30;3(1):96. doi: 10.1186/s40792-017-0373-4. PMID: 28856628; PMCID: PMC5577347.
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Surg Case Rep. 2017 Aug 30;3(1):96. doi: 10.1186/s40792-017-0373-4.

Primary colonic well-differentiated / dedifferentiated liposarcoma of the ascending colon: a case report.

Surgical case reports

Hiroshi Sawayama, Naoya Yoshida, Yuji Miyamoto, Tomoyuki Uchihara, Tasuku Toihata, Taisuke Yagi, Yukiharu Hiyoshi, Masaaki Iwatsuki, Yoshifumi Baba, Hideo Baba

Affiliations

  1. Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan.
  2. Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan. [email protected].

PMID: 28856628 PMCID: PMC5577347 DOI: 10.1186/s40792-017-0373-4

Abstract

BACKGROUND: Primary colonic and dedifferentiated liposarcomas are both remarkably rare. This work describes a case of primary colonic well-differentiated/dedifferentiated liposarcoma and reviews the clinical characteristics and current therapies for liposarcoma tumors.

CASE PRESENTATION: A 52-year-old woman was referred to our hospital with a submucosal tumor of the ascending colon. Clinical analysis by ultrasound colonoscopy and computed tomography revealed a partially ossified tumor with irregular edges continuous with the muscular layer. High F-18 deoxyglucose uptake was detected by positron emission tomography. Radical resection with lymph node dissection was performed, yielding a tumor specimen approximately 6.5 × 4.0 × 3.2 cm. Neoplastic spindle cell proliferation was found from submucosa to subserosa. Well-differentiated adipose tissue surrounded the tumor, but contained atypical nuclei with condensed chromosomes. Immunohistochemical staining was positive for p16, CDK4, and MDM2 expression. Based on these findings, a diagnosis of well-differentiated/dedifferentiated liposarcoma was given. Dedifferentiated liposarcomas are more aggressive than their well-differentiated, low-grade counterparts. While local recurrence can occur with both tumor types, dedifferentiated liposarcomas are more prone to developing distant metastases. The patient received no postoperative therapy, and no recurrences have been observed 12 months after surgery.

CONCLUSIONS: Here we report an extremely rare case of well-differentiated/dedifferentiated liposarcoma of the ascending colon. The dedifferentiated component was high-grade liposarcoma and well-differentiated liposarcoma was detected around the main tumor.

Keywords: CDK4; Dedifferentiated liposarcoma; MDM2; Primary colon; Well-differentiated liposarcoma; p16

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