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Factor SA, Scullin MK, Freeman A, et al. Affective Correlates of Psychosis in Parkinson's Disease. Mov Disord Clin Pract. 2016;4(2):225-230doi: 10.1002/mdc3.12381.
Factor, S. A., Scullin, M. K., Freeman, A., Bliwise, D. L., McDonald, W. M., & Goldstein, F. C. (2017). Affective Correlates of Psychosis in Parkinson's Disease. Movement disorders clinical practice, 4(2), 225-230. https://doi.org/10.1002/mdc3.12381
Factor, Stewart A, et al. "Affective Correlates of Psychosis in Parkinson's Disease." Movement disorders clinical practice vol. 4,2 (2017): 225-230. doi: https://doi.org/10.1002/mdc3.12381
Factor SA, Scullin MK, Freeman A, Bliwise DL, McDonald WM, Goldstein FC. Affective Correlates of Psychosis in Parkinson's Disease. Mov Disord Clin Pract. 2017 Mar-Apr;4(2):225-230. doi: 10.1002/mdc3.12381. Epub 2016 Jun 16. PMID: 28944257; PMCID: PMC5608273.
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Mov Disord Clin Pract. 2017 Mar-Apr;4(2):225-230. doi: 10.1002/mdc3.12381. Epub 2016 Jun 16.

Affective Correlates of Psychosis in Parkinson's Disease.

Movement disorders clinical practice

Stewart A Factor, Michael K Scullin, Alan Freeman, Donald L Bliwise, William M McDonald, Felicia C Goldstein

Affiliations

  1. Emory University School of Medicine: Department of Neurology.
  2. Baylor University, Department of Psychology and Neuroscience.
  3. Emory University School of Medicine: Department of Psychiatry.

PMID: 28944257 PMCID: PMC5608273 DOI: 10.1002/mdc3.12381

Abstract

OBJECTIVE: To examine the nature of the association between affective disorders and psychosis in Parkinson's disease (PD).

BACKGROUND: In PD, psychosis and affective disorders are common and independently impact quality of life and mortality. Both depression and psychosis are correlated with the occurrence of cognitive dysfunction, suggesting that they may share neurobiological substrates. Anxiety has not been examined as a correlate of psychosis.

METHODS: 144 PD subjects were evaluated with the Schedule for Assessment of Positive Symptoms to assess psychotic features, while depression and anxiety were examined by the Structured Clinical Interview for DSM-IV-TR (SCID) and self-assessment scales Beck Depression Inventory II (BDI-II) and Beck Anxiety Inventory (BAI). Correlational analyses assessed associations between hallucinations and delusions with depression and anxiety.

RESULTS: A diagnosis of anxiety (SCID) was significantly (p=.015) associated with hallucinations (OR=4.81, CI=1.36-16.99). Severity of anxiety (BAI) significantly predicted (p=.03) the presence of hallucinations (OR=1.08, CI=1.01-1.15) and delusions (OR=1.09, CR=1.01-1.17). Current depression (SCID) was significantly (p=.001) associated with the presence of hallucinations (OR=6.12, CI=2.04-18.39) and delusions (OR=7.14, CI=2.23-22.93). Multiple linear regressions revealed that severity of anxiety remained an independent predictor (p<.05) of both the number of types of hallucinations (t=3.06, p=.003) and delusions (t=2.87, p=.005). Severity of depression was a significant predictor of the total number of delusions (t=2.28, p=.024).

CONCLUSIONS: This study demonstrates an association between depression and psychosis and, for the first time, an association between anxiety and psychosis. These associations may have implications on pathophysiology and treatment of psychosis in PD.

Keywords: Anxiety; Delusions; Depression; Hallucinations; Parkinson’s disease

Conflict of interest statement

Conflict of interest There are no conflicts of interest from all authors that relate to the research covered in the article submitted.

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