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Zingone A, Brown D, Bowman ED, et al. Relationship between anti-depressant use and lung cancer survival. Cancer Treat Res Commun. 2017;10:33-39doi: 10.1016/j.ctarc.2017.01.001.
Zingone, A., Brown, D., Bowman, E. D., Vidal, O., Sage, J., Neal, J., & Ryan, B. M. (2017). Relationship between anti-depressant use and lung cancer survival. Cancer treatment and research communications, 1033-39. https://doi.org/10.1016/j.ctarc.2017.01.001
Zingone, Adriana, et al. "Relationship between anti-depressant use and lung cancer survival." Cancer treatment and research communications vol. 10 (2017): 33-39. doi: https://doi.org/10.1016/j.ctarc.2017.01.001
Zingone A, Brown D, Bowman ED, Vidal O, Sage J, Neal J, Ryan BM. Relationship between anti-depressant use and lung cancer survival. Cancer Treat Res Commun. 2017;10:33-39. doi: 10.1016/j.ctarc.2017.01.001. Epub 2017 Jan 29. PMID: 28944316; PMCID: PMC5603309.
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Cancer Treat Res Commun. 2017;10:33-39. doi: 10.1016/j.ctarc.2017.01.001. Epub 2017 Jan 29.

Relationship between anti-depressant use and lung cancer survival.

Cancer treatment and research communications

Adriana Zingone, Derek Brown, Elise D Bowman, Oscar Vidal, Julien Sage, Joel Neal, Bríd M Ryan

Affiliations

  1. Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892.
  2. Departments of Pediatrics and Genetics, Stanford University, Stanford CA, 94305.
  3. Department of Medicine, Division of Oncology.

PMID: 28944316 PMCID: PMC5603309 DOI: 10.1016/j.ctarc.2017.01.001

Abstract

OBJECTIVES: In recent years, the anti-cancer properties of several commonly used drugs have been explored, with drugs such as aspirin and beta-blockers associated with improved cancer outcomes. Previous preclinical work demonstrated that tricyclic anti-depressants have antitumor efficacy in lung cancer. Our goal was to examine the association between anti-depressant use and survival in lung cancer.

MATERIALS AND METHODS: We examined the association between use of common anti-depressants and survival in 1,097 lung cancer patients from the NCI-Maryland lung cancer study. The types of anti-depressants included in the study were norepinephrine and dopamine reuptake inhibitors, serotonin reuptake inhibitors, selective serotonin reuptake inhibitors, non-selective serotonin reuptake inhibitors, and tricyclic anti-depressants. Anti-depressant use was extracted from the medical history section of a detailed interviewer-administered questionnaire. Specific use in the three months before a lung cancer diagnosis was determined. Cox portioned hazards modeling was used to estimate the association between anti-depressant use with lung cancer-specific death with adjustment for potential confounding co-factors.

RESULTS: Anti-depressant use was associated with extended lung cancer-specific survival. In an analysis of specific classes of anti-depressant use, NDRIs and TCAs were associated with improved survival. Importantly, the extended survival associated with anti-depressants was maintained after adjustment for the clinical indications for these drugs, suggestive of a direct effect on lung cancer biology.

CONCLUSIONS: Considering the manageable and largely tolerable side effects of anti-depressants, and the low cost of these drugs, these results indicate that evaluation of anti-depressants as adjunct therapeutics with chemotherapy may have a translational effect for lung cancer patients.

Keywords: antidepressants; lung cancer; survival

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