Vet World. 2017 Aug;10(8):955-963. doi: 10.14202/vetworld.2017.955-963. Epub 2017 Aug 21.
Subchronic toxicity of Nile tilapia with different exposure routes to .
Veterinary world
H M R Abdel-Latif, A M Abou Khashaba
Affiliations
Affiliations
- Department of Poultry and Fish Diseases, Faculty of Veterinary Medicine, Alexandria University (Matrouh Branch), Fuka City, Box: 51744, Matrouh Province, Egypt.
- Department of Food Inspection, Animal Health Research Institute, Dokki, Giza Province, Egypt.
PMID: 28919690
PMCID: PMC5591486 DOI: 10.14202/vetworld.2017.955-963
Abstract
BACKGROUND: Toxic cyanobacterial blooms (
AIM: Three-week subchronic exposure experiment was carried out on Nile tilapia, to determine their effects on fish behavior, tissues, liver functions, antioxidant enzymes, and lipid peroxidation.
MATERIALS AND METHODS: Fish were exposed to four main treatments; orally fed diet plus toxic cells of
RESULTS: The results revealed no recorded mortality with obvious behavioral changes and an enlarged liver with the congested gall bladder. Histopathology demonstrated fragmentation, hyalinization, and necrosis of the subcutaneous musculature marked fatty degeneration, and vacuolation of hepatopancreatic cells with adhesion of the secondary gill lamellae associated with severe leukocytic infiltration. Furthermore, liver functions enzymes (aspartate aminotransferase and alanine aminotransferase, and the activities of glutathione peroxidase, glutathione reductase, lipid peroxidase, and catalase enzymes) were significantly increased in all treatments starting from the 2
CONCLUSION: In this context, the study addresses the possible toxicological impacts of toxic
Keywords: Microcystis aeruginosa; Nile tilapia; catalase; lipid peroxidation; microcystins
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