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Jenabi A, Jabbari M, Ziaie H. Comparing the values of intact parathormone and 1- 84 PTH to predict hyperparathyroidism in hemodialysis patients. J Nephropathol. 2017;6(3):248-253doi: 10.15171/jnp.2017.40.
Jenabi, A., Jabbari, M., & Ziaie, H. (2017). Comparing the values of intact parathormone and 1- 84 PTH to predict hyperparathyroidism in hemodialysis patients. Journal of nephropathology, 6(3), 248-253. https://doi.org/10.15171/jnp.2017.40
Jenabi, Aria, et al. "Comparing the values of intact parathormone and 1- 84 PTH to predict hyperparathyroidism in hemodialysis patients." Journal of nephropathology vol. 6,3 (2017): 248-253. doi: https://doi.org/10.15171/jnp.2017.40
Jenabi A, Jabbari M, Ziaie H. Comparing the values of intact parathormone and 1- 84 PTH to predict hyperparathyroidism in hemodialysis patients. J Nephropathol. 2017 Jul;6(3):248-253. doi: 10.15171/jnp.2017.40. Epub 2017 Apr 22. PMID: 28975108; PMCID: PMC5607990.
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J Nephropathol. 2017 Jul;6(3):248-253. doi: 10.15171/jnp.2017.40. Epub 2017 Apr 22.

Comparing the values of intact parathormone and 1- 84 PTH to predict hyperparathyroidism in hemodialysis patients.

Journal of nephropathology

Aria Jenabi, Mosadegh Jabbari, Hossein Ziaie

Affiliations

  1. Nephrology ward, Rasoul Akram Medical Center, Iran University of Medical Sciences Tehran Iran.

PMID: 28975108 PMCID: PMC5607990 DOI: 10.15171/jnp.2017.40

Abstract

BACKGROUND: Secondary hyperparathyroidism (SHPT) is a common complication of chronic kidney disease (CKD) leading high mortality and even long-term morbidity. SHPT is manifested by elevation of parathyroid hormone (PTH) and accurate determining the level of serum PTH is very essential for early diagnosis of SHPT secondary to CKD. It is very important to match the values obtained for intact parathormone (iPTH) and 1- 84 PTH with the minimized measurement bias.

OBJECTIVES: The present study aimed to first determine the agreement value between the iPTH and 1- 84 PTH measures in patients with hyperparathyroidism secondary to endstage renal disease under chronic hemodialysis. Then, we attempted to determine the best cutoff values for these two measurements for detecting SHPT in such patients.

PATIENTS AND METHODS: This cross-sectional study was conducted on hemodialysis patients. The value of study biomarkers including iPTH and 1- 84 PTH was assessed.

RESULTS: A strong positive association was revealed between the two indicators of iPTH and 1-84 PTH (r = 0.800,

CONCLUSIONS: The measurement of both iPTH and 1-84 PTH is valuable for predicting hyperparathyroidism secondary to CKD, but according to lower cost and comparableeffectiveness of iPTH measurement, this assay may be comparable to 1-84 PTH to predict this consequence.

Keywords: 1-84 PTH; Bio-active PTH; Chronic kidney disease ; ESRD; Hemodialysis; Intact parathormone; iPTH

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