Rapid Commun Mass Spectrom. 2017 Dec 15;31(23):1957-1962. doi: 10.1002/rcm.7977.
Ion suppression effect in desorption electrospray ionization and electrospray ionization mass spectrometry.
Rapid communications in mass spectrometry : RCM
Zheng Wang, Haijing Zhu, Guangming Huang
Affiliations
Affiliations
- Department of Chemistry, School of Chemistry and Materials Science, University of Science and Technology of China (USTC), Hefei, 230026, China.
PMID: 28857292
DOI: 10.1002/rcm.7977
Abstract
RATIONALE: Although it is claimed that desorption electrospray ionization (DESI) causes less ion suppression effects than electrospray ionization (ESI), a related investigation with quantification measurement of ion suppression effects is absent. Herein, a comparative analysis of ion suppression effects between DESI and ESI was conducted, with the aiming of quantitatively studying the ion suppression effect.
METHODS: CTVA mixtures, a constant concentration of tioconazole with varied concentrations of atenolol, were analyzed by ESI and DESI. The ion suppression effect was characterized by the signal loss of tioconazole in the mixture compared to the signal intensity of tioconazole without interference (denoted as (I
RESULTS: With the increasing flow rate, the ion suppression effect in DESI became weaker, while the opposite trend was obtained for ESI. As for capillary inner diameter, a smaller inner diameter resulted in weaker ion suppression effects in DESI and ESI. The solvent composition affected the ion suppression effect, and the PTFE substrate presented the weakest ion suppression effect among the five substrate materials.
CONCLUSIONS: Though the ion suppression effect in DESI and ESI was shown to relate to experimental conditions, DESI had less effect than ESI under the same experimental conditions in most cases. Moreover, DESI displayed stronger matrix-tolerant ability than ESI which is also attributed to the weaker ion suppression effect.
Copyright © 2017 John Wiley & Sons, Ltd.
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