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Oncoimmunology. 2017 Jun 19;6(8):e1336593. doi: 10.1080/2162402X.2017.1336593. eCollection 2017.

Reciprocal influence of B cells and tumor macro and microenvironments in the .

Oncoimmunology

Francesca Mion, Stefania Vetrano, Silvia Tonon, Viviana Valeri, Andrea Piontini, Alessia Burocchi, Luciana Petti, Barbara Frossi, Alessandro Gulino, Claudio Tripodo, Mario P Colombo, Carlo E Pucillo

Affiliations

  1. Department of Medicine, University of Udine, Udine, Italy.
  2. Inflammatory Bowel Disease Center, Humanitas Research Hospital, Rozzano, Italy.
  3. Department of Biomedical Sciences, Humanitas University, Milano, Italy.
  4. Department of Experimental Oncology and Molecular Medicine, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy.
  5. Department of Biotechnology and Translational Medicine, University of Milan, Milano, Italy.
  6. Department of Health Science, Tumor Immunology Unit, Human Pathology Section, Palermo University School of Medicine, Palermo, Italy.

PMID: 28919998 PMCID: PMC5593718 DOI: 10.1080/2162402X.2017.1336593

Abstract

One of the most fascinating aspects of the immune system is its dynamism, meant as the ability to change and readapt according to the organism needs. Following an insult, we assist to the spontaneous organization of different immune cells which cooperate, locally and at distance, to build up an appropriate response. Throughout tumor progression, adaptations within the systemic tumor environment, or macroenvironment, result in the promotion of tumor growth, tumor invasion and metastasis to distal organs, but also to dramatic changes in the activity and composition of the immune system. In this work, we show the changes of the B-cell arm of the immune system following tumor progression in the

Keywords: ApcMin/+ mice; B lymphocytes; IL-10; IgA; intestinal cancer

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