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Fakhari A, Corcoran M, Schwarz A. Thermogelling properties of purified poloxamer 407. Heliyon. 2017;3(8):e00390doi: 10.1016/j.heliyon.2017.e00390.
Fakhari, A., Corcoran, M., & Schwarz, A. (2017). Thermogelling properties of purified poloxamer 407. Heliyon, 3(8), e00390. https://doi.org/10.1016/j.heliyon.2017.e00390
Fakhari, Amir, et al. "Thermogelling properties of purified poloxamer 407." Heliyon vol. 3,8 (2017): e00390. doi: https://doi.org/10.1016/j.heliyon.2017.e00390
Fakhari A, Corcoran M, Schwarz A. Thermogelling properties of purified poloxamer 407. Heliyon. 2017 Aug 30;3(8):e00390. doi: 10.1016/j.heliyon.2017.e00390. eCollection 2017 Aug. PMID: 28920092; PMCID: PMC5576961.
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Heliyon. 2017 Aug 30;3(8):e00390. doi: 10.1016/j.heliyon.2017.e00390. eCollection 2017 Aug.

Thermogelling properties of purified poloxamer 407.

Heliyon

Amir Fakhari, Marta Corcoran, Alexander Schwarz

Affiliations

  1. Drug Delivery and Device Development, Medimmune LLC, United States.

PMID: 28920092 PMCID: PMC5576961 DOI: 10.1016/j.heliyon.2017.e00390

Abstract

Poloxamers are triblock copolymers with a center block of hydrophobic polypropylene oxide (PPO) flanked by two hydrophilic polyethyleneoxide (PEO) blocks. Among this family of copolymers, poloxamer 407 is a non-ionic surfactant with reversible gelation properties above a particular polymer concentration and a particular temperature. Easy preparation of poloxamer 407 based sterile injectable formulations have made this copolymer a good candidate for drug delivery, specifically when controlled release of the drug is required. Previously, the applications of compendial poloxamer 407 preparations were demonstrated; however, low viscosity, poor elasticity, and sol-to-gel transition temperature (T

Keywords: Bioengineering; Materials Science

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