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Acc Chem Res. 2017 Mar 21;50(3):620-626. doi: 10.1021/acs.accounts.6b00621.

Large-Scale Selective Functionalization of Alkanes.

Accounts of chemical research

Karen I Goldberg, Alan S Goldman

Affiliations

  1. Department of Chemistry, University of Washington , Box 351700, Seattle, Washington 98195, United States.
  2. Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey , New Brunswick, New Jersey 08903, United States.

PMID: 28945401 DOI: 10.1021/acs.accounts.6b00621

Abstract

Great progress has been made in the past several decades concerning C-H bond functionalization. But despite many significant advances, a commercially viable large-scale process for selective alkane functionalization remains an unreached goal. Such conversions will require highly active, selective, and long-lived catalysts. In addition, essentially complete atom-economy will be required. Thus, any reagents used in transforming the alkanes must be almost free (e.g., O

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