Acc Chem Res. 2017 Mar 21;50(3):620-626. doi: 10.1021/acs.accounts.6b00621.
Accounts of chemical research
Karen I Goldberg, Alan S Goldman
PMID: 28945401 DOI: 10.1021/acs.accounts.6b00621
Great progress has been made in the past several decades concerning C-H bond functionalization. But despite many significant advances, a commercially viable large-scale process for selective alkane functionalization remains an unreached goal. Such conversions will require highly active, selective, and long-lived catalysts. In addition, essentially complete atom-economy will be required. Thus, any reagents used in transforming the alkanes must be almost free (e.g., O