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Tripathi M, Singh PK, Ambesh SP, et al. Target controlled priming for rapid onset of intubation dose: A new approach. J Anesth. 1997;11(4):255-259doi: 10.1007/BF02480740.
Tripathi, M., Singh, P. K., Ambesh, S. P., & Kaushik, S. (1997). Target controlled priming for rapid onset of intubation dose: A new approach. Journal of anesthesia, 11(4), 255-259. https://doi.org/10.1007/BF02480740
Tripathi, Mukesh, et al. "Target controlled priming for rapid onset of intubation dose: A new approach." Journal of anesthesia vol. 11,4 (1997): 255-259. doi: https://doi.org/10.1007/BF02480740
Tripathi M, Singh PK, Ambesh SP, Kaushik S. Target controlled priming for rapid onset of intubation dose: A new approach. J Anesth. 1997 Dec;11(4):255-259. doi: 10.1007/BF02480740. PMID: 28921062.
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J Anesth. 1997 Dec;11(4):255-259. doi: 10.1007/BF02480740.

Target controlled priming for rapid onset of intubation dose: A new approach.

Journal of anesthesia

Mukesh Tripathi, Prabhat K Singh, Sushil P Ambesh, Soma Kaushik

Affiliations

  1. Department of Anaesthesiology and Critical Care Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Pin-226 014, Lucknow, India.

PMID: 28921062 DOI: 10.1007/BF02480740

Abstract

PURPOSE: To determine the pattern of onset of the intubating dose when given at a monitored target priming block in either phase of the priming drug effect.

METHODS: Sixty consenting ASA I and II patients were premedicated by intramuscular buprenorphine (5 μg·kg

RESULTS: We observed that in spite of significantly variable priming intervals for identical DBSr in two different phases, the onset time of the intubating dose to 0 response was identical in similar DBSr group patients; i.e., at 0.8 DBSr, 65.0±5.2s (group 1)vs 66.0±8.0s (group 2); at DBSr 0.6, 55.2±3.7s (group 3)vs 55.2±4.9s (group 4); and at DBSr 0.5, 43.5±4.8s (group 5)vs 43.5±4.2s (group 6). At 0 twitch response, the intubating conditions were comparable in patients of the six groups.

CONCLUSION: In conclusion, target controlled priming (DBSr) for administration of the intubating dose appears to be a useful double-vision sign to predict the onset of the effect of the intubating dose precisely.

Keywords: Doubleburst stimulation; Neuromuscular monitoring; Priming; Vecuronium

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