Display options
Cite
Yorozu T, Morisaki H, Kondoh M, et al. Epidural anesthesia during hysterectomy diminishes postoperative pain and urinary cortisol release. J Anesth. 1997;11(4):260-264doi: 10.1007/BF02480741.
Yorozu, T., Morisaki, H., Kondoh, M., Tomizawa, K., Satoh, M., & Shigematsu, T. (1997). Epidural anesthesia during hysterectomy diminishes postoperative pain and urinary cortisol release. Journal of anesthesia, 11(4), 260-264. https://doi.org/10.1007/BF02480741
Yorozu, Tomoko, et al. "Epidural anesthesia during hysterectomy diminishes postoperative pain and urinary cortisol release." Journal of anesthesia vol. 11,4 (1997): 260-264. doi: https://doi.org/10.1007/BF02480741
Yorozu T, Morisaki H, Kondoh M, Tomizawa K, Satoh M, Shigematsu T. Epidural anesthesia during hysterectomy diminishes postoperative pain and urinary cortisol release. J Anesth. 1997 Dec;11(4):260-264. doi: 10.1007/BF02480741. PMID: 28921063.
Copy Download .nbib Format: NLM
Share it on

J Anesth. 1997 Dec;11(4):260-264. doi: 10.1007/BF02480741.

Epidural anesthesia during hysterectomy diminishes postoperative pain and urinary cortisol release.

Journal of anesthesia

Tomoko Yorozu, Hiroshi Morisaki, Masahiro Kondoh, Kazuo Tomizawa, Masato Satoh, Toshiyuki Shigematsu

Affiliations

  1. Department of Anesthesia, Tokyo Metropolitan Otsuka Hospital, 2-8-1 Minami-Otsuka, Toshima-ku, 170, Tokyo, Japan.
  2. Department of Anesthesiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160, Tokyo, Japan.

PMID: 28921063 DOI: 10.1007/BF02480741

Abstract

PURPOSE: To examine the hypothesis that epidural anesthesia throughout lower abdominal surgery would depress both postoperative pain and cortisol release.

METHODS: Forty adult patients undergoing abdominal total hysterectomy were studied. The patients were randomly assigned to two groups. Group G received general anesthesia alone (sevoflurane 1.5%-2.5%); group E received a combination of epidural anesthesia (1.5% mepivacaine) with a light plane of general anesthesia (sevoflurane<0.5%). Postoperative analgesia was obtained epidurally by patient-controlled analgesia. Postoperative pain at rest and during movement was assessed by a visual analogue scale (VAS) at 2, 24, and 48 h following surgery. The plasma concentration and urinary excretion of cortisol were measured during the perioperative period.

RESULTS: VAS values were lower in group E than in group G during movement at 24h (4.6±0.5vs 6.1±0.4 cm). Urinary cortisol excretion on the first postoperative day was less in group E than in group G (192±34vs 480±120μg).

CONCLUSIONS: Epidural blockade prior to surgical stimuli and throughout lower abdominal surgery reduces the postoperative dynamic pain and stress response.

Keywords: Cortisol; Epidural anesthesia; Hysterectomy; Preemptive analgesia; Visual analogue scale

References

  1. Pain. 1988 Jun;33(3):289-90 - PubMed
  2. Nature. 1983 Dec 15-21;306(5944):686-8 - PubMed
  3. J Endocrinol. 1966 May;35(1):29-44 - PubMed
  4. Can J Anaesth. 1990 May;37(4 Pt 1):429-31 - PubMed
  5. Arch Intern Med. 1987 Jul;147(7):1273-8 - PubMed
  6. Surgery. 1957 Jun;41(6):895-909 - PubMed
  7. Anesth Analg. 1990 Jan;70(1):29-35 - PubMed
  8. Anaesthesia. 1993 Feb;48(2):120-3 - PubMed
  9. Pain. 1991 Apr;45(1):69-75 - PubMed
  10. Clin Sci Mol Med. 1974 Mar;46(3):403-7 - PubMed
  11. Pain. 1994 Dec;59(3):395-403 - PubMed
  12. Masui. 1986 Jun;35(6):924-8 - PubMed
  13. Anesthesiology. 1993 Apr;78(4):713-21 - PubMed
  14. Br J Anaesth. 1989 Mar;62(3):253-7 - PubMed
  15. Acta Endocrinol (Copenh). 1980 Jun;94(2):151-4 - PubMed
  16. Exp Neurol. 1972 Nov;37(2):371-87 - PubMed
  17. Br J Anaesth. 1992 Jul;69(1):4-8 - PubMed
  18. Surgery. 1988 Mar;103(3):321-7 - PubMed
  19. Metabolism. 1977 Sep;26(9):989-97 - PubMed
  20. Anesthesiology. 1992 Sep;77(3):439-46 - PubMed
  21. Anesth Analg. 1992 Apr;74(4):495-8 - PubMed
  22. J Anesth. 1996 Mar;10(1):10-5 - PubMed

Publication Types