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Nonaka A, Kashimoto S, Iwashita H, et al. Halothane suppresses the increase in intracellular calcium concentration of isolated rat myocytes during hydrogen peroxide perfusion. J Anesth. 1995;9(3):260-264doi: 10.1007/BF02479875.
Nonaka, A., Kashimoto, S., Iwashita, H., & Kumazawa, T. (1995). Halothane suppresses the increase in intracellular calcium concentration of isolated rat myocytes during hydrogen peroxide perfusion. Journal of anesthesia, 9(3), 260-264. https://doi.org/10.1007/BF02479875
Nonaka, Akihiko, et al. "Halothane suppresses the increase in intracellular calcium concentration of isolated rat myocytes during hydrogen peroxide perfusion." Journal of anesthesia vol. 9,3 (1995): 260-264. doi: https://doi.org/10.1007/BF02479875
Nonaka A, Kashimoto S, Iwashita H, Kumazawa T. Halothane suppresses the increase in intracellular calcium concentration of isolated rat myocytes during hydrogen peroxide perfusion. J Anesth. 1995 Sep;9(3):260-264. doi: 10.1007/BF02479875. PMID: 28921228.
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J Anesth. 1995 Sep;9(3):260-264. doi: 10.1007/BF02479875.

Halothane suppresses the increase in intracellular calcium concentration of isolated rat myocytes during hydrogen peroxide perfusion.

Journal of anesthesia

Akihiko Nonaka, Satoshi Kashimoto, Hironobu Iwashita, Teruo Kumazawa

Affiliations

  1. Department of Anesthesiology, Yamanashi Medical University, 1110 Shimokato, Tamaho-cho, Nakakoma-gun, 409-38, Yamanashi, Japan.

PMID: 28921228 DOI: 10.1007/BF02479875

Abstract

Ischemia-reperfusion injury is probably caused by the generation of oxygen free radicals. The final common pathway to cell injury may be mediated by intracellular calcium overloading induced by oxygen free radicals. Volatile anesthetics have been shown to improve myocardial function following reperfusion. To determine whether or not oxygen radicals are involved in the mechanism by which volatile anesthetics improve myocardial function following reperfusion, we investigated the effects of hydrogen peroxide (H

Keywords: Calcium ion; Free radicals; Inhalational anesthetics; Myocytes

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