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Egan TD. The clinical pharmacology of remifentanil: a brief review. J Anesth. 1998;12(4):195-204doi: 10.1007/BF02481730.
Egan, T. D. (1998). The clinical pharmacology of remifentanil: a brief review. Journal of anesthesia, 12(4), 195-204. https://doi.org/10.1007/BF02481730
Egan, Talmage D. "The clinical pharmacology of remifentanil: a brief review." Journal of anesthesia vol. 12,4 (1998): 195-204. doi: https://doi.org/10.1007/BF02481730
Egan TD. The clinical pharmacology of remifentanil: a brief review. J Anesth. 1998 Dec;12(4):195-204. doi: 10.1007/BF02481730. PMID: 28921316.
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J Anesth. 1998 Dec;12(4):195-204. doi: 10.1007/BF02481730.

The clinical pharmacology of remifentanil: a brief review.

Journal of anesthesia

Talmage D Egan

Affiliations

  1. Department of Anesthesiology, University Health Sciences Center, 50 North Medical Dr., 84132, Salt Lake City, UT, USA.

PMID: 28921316 DOI: 10.1007/BF02481730

Abstract

Because it is still in its clinical infancy, it is difficult to predict with confidence exactly what role remifentanil will ultimately play in the delivery of anesthesia (and in other settings). It is clear, however, that remifentanil is a new pharmacologic tool with exciting potential that was not possible with the longer-acting opioids. On the basis of its familiar, fentanyl-like pharmacodynamic behavior and its short-acting pharmacokinetic profile, remifentanil may well be advantageous in a variety of settings in which profound opioid effect with subsequent rapid return of spontaneous ventilation and consciousness is desirable. Ongoing research and wide-spread clinical use will be required before the theoretical advantages associated with a short-acting opioid can be fully explored and confirmed.

Keywords: Pharmacodynamics; Pharmacokinetics; Remifentanil

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