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Hu Y, Wang Z, Pan S, et al. Inhibition of endoplasmic reticulum stress is involved in the neuroprotective effect of aFGF in neonatal hypoxic-ischaemic brain injury. Oncotarget. 2017;8(37):60941-60953doi: 10.18632/oncotarget.17524.
Hu, Y., Wang, Z., Pan, S., Fang, M., Jiang, H., Mao, Y., Zhang, H., Ji, Y., Zhang, F., Lin, L., Lin, Z., & Xiao, J. (2017). Inhibition of endoplasmic reticulum stress is involved in the neuroprotective effect of aFGF in neonatal hypoxic-ischaemic brain injury. Oncotarget, 8(37), 60941-60953. https://doi.org/10.18632/oncotarget.17524
Hu, Yingying, et al. "Inhibition of endoplasmic reticulum stress is involved in the neuroprotective effect of aFGF in neonatal hypoxic-ischaemic brain injury." Oncotarget vol. 8,37 (2017): 60941-60953. doi: https://doi.org/10.18632/oncotarget.17524
Hu Y, Wang Z, Pan S, Fang M, Jiang H, Mao Y, Zhang H, Ji Y, Zhang F, Lin L, Lin Z, Xiao J. Inhibition of endoplasmic reticulum stress is involved in the neuroprotective effect of aFGF in neonatal hypoxic-ischaemic brain injury. Oncotarget. 2017 Apr 29;8(37):60941-60953. doi: 10.18632/oncotarget.17524. eCollection 2017 Sep 22. PMID: 28977836; PMCID: PMC5617396.
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Oncotarget. 2017 Apr 29;8(37):60941-60953. doi: 10.18632/oncotarget.17524. eCollection 2017 Sep 22.

Inhibition of endoplasmic reticulum stress is involved in the neuroprotective effect of aFGF in neonatal hypoxic-ischaemic brain injury.

Oncotarget

Yingying Hu, Zhouguang Wang, Shulin Pan, Mingchu Fang, Huai Jiang, Yuqin Mao, Hao Zhang, Yiming Ji, Fabiao Zhang, Li Lin, Zhenlang Lin, Jian Xiao

Affiliations

  1. Department of Neonatology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
  2. Molecular Pharmacology Research Center, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
  3. Department of Hepatobiliary Surgery, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, 317000, China.

PMID: 28977836 PMCID: PMC5617396 DOI: 10.18632/oncotarget.17524

Abstract

Acidic fibroblast growth factor (aFGF) has been shown to exert neuroprotective effects in experimental models and human patients. In this study, we investigated whether aFGF intranasal-treatment protected against neonatal hypoxic-ischaemic brain injury and evaluated the role of endoplasmic reticulum stress. The Rice-Vannucci model of neonatal hypoxic-ischaemic brain injury was used in 7-day-old rats, which were subjected to unilateral carotid artery ligation followed by 2.5 h of hypoxia. Intranasal aFGF or vehicle was administered immediately after hypoxic-ischaemic injury (100 ng/g) and then twice a day for 1 week to evaluate the long-term effects. Here we reported that intranasal-treatment with aFGF significantly reduced hypoxic-ischaemic brain infarct volumes and the protective effects were at least partially via inhibiting endoplasmic reticulum stress. In addition, aFGF exerted long-term neuroprotective effects against brain atrophy and neuron loss at 7-day after injury. Our data indicate that therapeutic strategies targeting endoplasmic reticulum stress may be promising to the treatment of neonatal hypoxic-ischaemic brain injury.

Keywords: acidic fibroblast growth factor; endoplasmic reticulum stress; intranasal; neonatal hypoxic-ischaemic brain injury

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare that they have no competing interests.

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