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Chen CY, Chen YY, Chen JJW, et al. Astrocyte-elevated gene-1 confers resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase expression. Oncotarget. 2017;8(37):61901-61916doi: 10.18632/oncotarget.18717.
Chen, C. Y., Chen, Y. Y., Chen, J. J. W., Chen, K. Y., Ho, C. C., Shih, J. Y., Chang, Y. L., Yu, C. J., & Yang, P. C. (2017). Astrocyte-elevated gene-1 confers resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase expression. Oncotarget, 8(37), 61901-61916. https://doi.org/10.18632/oncotarget.18717
Chen, Chung-Yu, et al. "Astrocyte-elevated gene-1 confers resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase expression." Oncotarget vol. 8,37 (2017): 61901-61916. doi: https://doi.org/10.18632/oncotarget.18717
Chen CY, Chen YY, Chen JJW, Chen KY, Ho CC, Shih JY, Chang YL, Yu CJ, Yang PC. Astrocyte-elevated gene-1 confers resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase expression. Oncotarget. 2017 Jun 28;8(37):61901-61916. doi: 10.18632/oncotarget.18717. eCollection 2017 Sep 22. PMID: 28977913; PMCID: PMC5617473.
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Oncotarget. 2017 Jun 28;8(37):61901-61916. doi: 10.18632/oncotarget.18717. eCollection 2017 Sep 22.

Astrocyte-elevated gene-1 confers resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase expression.

Oncotarget

Chung-Yu Chen, Ying-Yin Chen, Jeremy J W Chen, Kuan-Yu Chen, Chao-Chi Ho, Jin-Yuan Shih, Yih-Leong Chang, Chong-Jen Yu, Pan-Chyr Yang

Affiliations

  1. Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Douliu, Taiwan.
  2. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
  3. Department of Pathology and Graduate Institute of Pathology, College of Medicine, National Taiwan University, Taipei, Taiwan.
  4. Institute of Biomedical Science, College of Life Sciences, National Chung Hsing University, Taichung, Taiwan.

PMID: 28977913 PMCID: PMC5617473 DOI: 10.18632/oncotarget.18717

Abstract

Previous studies have suggested that astrocyte-elevated gene-1 (AEG-1) contributes to the mechanisms of resistance to various chemotherapeutics. In this study, we investigated whether AEG-1 expression level correlated with that of thymidylate synthase (TS), as higher TS expression is known to be associated with the resistance to pemetrexed chemotherapy in patients with advanced lung adenocarcinoma. Using pemetrexed-resistant lung adenocarcinoma PC-9 cell line, we demonstrated that transfection of AEG-1 siRNA lowered TS expression and decreased pemetrexed IC

Keywords: astrocyte elevated gene-1; chemoresistance; lung cancer; pemetrexed; thymidylate synthase

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no conflicts of interest.

References

  1. Histopathology. 2015 Dec;67(6):817-26 - PubMed
  2. BMC Pulm Med. 2015 Oct 26;15:132 - PubMed
  3. Cancer. 2006 Oct 1;107(7):1589-96 - PubMed
  4. J Clin Oncol. 2008 Jul 20;26(21):3543-51 - PubMed
  5. Lung Cancer. 2013 Jul;81(1):102-8 - PubMed
  6. J Clin Oncol. 2013 Aug 10;31(23):2895-902 - PubMed
  7. PLoS One. 2013 May 13;8(5):e63338 - PubMed
  8. Med Oncol. 2013 Mar;30(1):383 - PubMed
  9. Cell Cycle. 2014;13(11):1702-7 - PubMed
  10. Tumour Biol. 2016 Jul;37(7):9465-72 - PubMed
  11. J Thorac Oncol. 2013 Jan;8(1):19-30 - PubMed
  12. Br J Cancer. 2010 Jul 27;103(3):354-61 - PubMed
  13. J Clin Oncol. 2004 May 1;22(9):1589-97 - PubMed
  14. PLoS One. 2013 Sep 10;8(9):e74284 - PubMed
  15. J Natl Compr Canc Netw. 2012 Oct 1;10(10):1236-71 - PubMed
  16. J Cancer Res Clin Oncol. 2014 Dec;140(12):2047-57 - PubMed
  17. J Biomed Sci. 2013 Jan 25;20:5 - PubMed
  18. Cancer Cell. 2009 Jan 6;15(1):9-20 - PubMed
  19. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17390-5 - PubMed
  20. Eur J Cancer. 2009 Jan;45(2):228-47 - PubMed
  21. BMC Cancer. 2014 Mar 19;14:205 - PubMed
  22. Mol Cells. 2014 Dec 31;37(12):857-64 - PubMed
  23. Oncol Lett. 2014 Aug;8(2):493-501 - PubMed
  24. Anticancer Res. 2013 May;33(5):1935-40 - PubMed
  25. Transl Lung Cancer Res. 2014 Apr;3(2):107-15 - PubMed
  26. Cancer Chemother Pharmacol. 2013 Nov;72(5):1125-32 - PubMed
  27. Lung Cancer. 2010 Oct;70(1):63-70 - PubMed
  28. Pharmacol Ther. 2007 May;114(2):155-70 - PubMed
  29. J Clin Oncol. 2009 Dec 20;27(36):6251-66 - PubMed
  30. Adv Cancer Res. 2013;120:135-57 - PubMed
  31. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12938-43 - PubMed
  32. J Pathol. 2009 Nov;219(3):317-26 - PubMed
  33. Cancer Res. 1997 Mar 15;57(6):1116-23 - PubMed
  34. CA Cancer J Clin. 2016 Jan-Feb;66(1):7-30 - PubMed
  35. J Exp Clin Cancer Res. 2009 Feb 15;28:19 - PubMed
  36. Clin Cancer Res. 2009 Sep 15;15(18):5615-20 - PubMed
  37. J Clin Oncol. 2015 Oct 20;33(30):3488-515 - PubMed
  38. Clin Transl Oncol. 2016 Jan;18(1):107-12 - PubMed
  39. J Thorac Oncol. 2013 Jul;8(7):930-9 - PubMed
  40. Cancer Res. 2010 Apr 15;70(8):3249-58 - PubMed
  41. Lancet. 2009 Oct 24;374(9699):1432-40 - PubMed

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