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Hilborn E, Stål O, Alexeyenko A, et al. The regulation of hydroxysteroid 17β-dehydrogenase type 1 and 2 gene expression in breast cancer cell lines by estradiol, dihydrotestosterone, microRNAs, and genes related to breast cancer. Oncotarget. 2017;8(37):62183-62194doi: 10.18632/oncotarget.19136.
Hilborn, E., Stål, O., Alexeyenko, A., & Jansson, A. (2017). The regulation of hydroxysteroid 17β-dehydrogenase type 1 and 2 gene expression in breast cancer cell lines by estradiol, dihydrotestosterone, microRNAs, and genes related to breast cancer. Oncotarget, 8(37), 62183-62194. https://doi.org/10.18632/oncotarget.19136
Hilborn, Erik, et al. "The regulation of hydroxysteroid 17β-dehydrogenase type 1 and 2 gene expression in breast cancer cell lines by estradiol, dihydrotestosterone, microRNAs, and genes related to breast cancer." Oncotarget vol. 8,37 (2017): 62183-62194. doi: https://doi.org/10.18632/oncotarget.19136
Hilborn E, Stål O, Alexeyenko A, Jansson A. The regulation of hydroxysteroid 17β-dehydrogenase type 1 and 2 gene expression in breast cancer cell lines by estradiol, dihydrotestosterone, microRNAs, and genes related to breast cancer. Oncotarget. 2017 Jul 10;8(37):62183-62194. doi: 10.18632/oncotarget.19136. eCollection 2017 Sep 22. PMID: 28977936; PMCID: PMC5617496.
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Oncotarget. 2017 Jul 10;8(37):62183-62194. doi: 10.18632/oncotarget.19136. eCollection 2017 Sep 22.

The regulation of hydroxysteroid 17β-dehydrogenase type 1 and 2 gene expression in breast cancer cell lines by estradiol, dihydrotestosterone, microRNAs, and genes related to breast cancer.

Oncotarget

Erik Hilborn, Olle Stål, Andrey Alexeyenko, Agneta Jansson

Affiliations

  1. Department of Clinical and Experimental Medicine and Department of Oncology, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
  2. Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden.
  3. National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Solna, Sweden.

PMID: 28977936 PMCID: PMC5617496 DOI: 10.18632/oncotarget.19136

Abstract

AIM: To investigate the influence of estrogen, androgen, microRNAs, and genes implicated in breast cancer on the expression of HSD17B1 and HSD17B2.

MATERIALS: Breast cancer cell lines ZR-75-1, MCF7, T47D, SK-BR-3, and the immortalized epithelial cell line MCF10A were used. Cells were treated either with estradiol or dihydrotestosterone for 6, 24, 48 hours, or 7 days or treated with miRNAs or siRNAs predicted to influence HSD17B expression Results and discussion. Estradiol treatment decreased

CONCLUSION: We show that

Keywords: HSD17B1; HSD17B2; breast cancer; miRNA

Conflict of interest statement

CONFLICTS OF INTEREST There are no conflicts of interest for any of the authors at the time of submission.

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