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Li X, Shen JK, Hornicek FJ, et al. Noncoding RNA in drug resistant sarcoma. Oncotarget. 2017;8(40):69086-69104doi: 10.18632/oncotarget.19029.
Li, X., Shen, J. K., Hornicek, F. J., Xiao, T., & Duan, Z. (2017). Noncoding RNA in drug resistant sarcoma. Oncotarget, 8(40), 69086-69104. https://doi.org/10.18632/oncotarget.19029
Li, Xiaoyang, et al. "Noncoding RNA in drug resistant sarcoma." Oncotarget vol. 8,40 (2017): 69086-69104. doi: https://doi.org/10.18632/oncotarget.19029
Li X, Shen JK, Hornicek FJ, Xiao T, Duan Z. Noncoding RNA in drug resistant sarcoma. Oncotarget. 2017 Jul 06;8(40):69086-69104. doi: 10.18632/oncotarget.19029. eCollection 2017 Sep 15. PMID: 28978183; PMCID: PMC5620323.
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Oncotarget. 2017 Jul 06;8(40):69086-69104. doi: 10.18632/oncotarget.19029. eCollection 2017 Sep 15.

Noncoding RNA in drug resistant sarcoma.

Oncotarget

Xiaoyang Li, Jacson K Shen, Francis J Hornicek, Tao Xiao, Zhenfeng Duan

Affiliations

  1. Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
  2. Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, 02114, USA.

PMID: 28978183 PMCID: PMC5620323 DOI: 10.18632/oncotarget.19029

Abstract

Sarcomas are a group of malignant tumors that arise from mesenchymal origin. Despite significant development of multidisciplinary treatments for sarcoma, survival rates have reached a plateau. Chemotherapy has been extensively used for sarcoma treatment; however, the development of drug resistance is a major obstacle limiting the success of many anticancer agents. Sarcoma biology has traditionally focused on genomic and epigenomic deregulation of protein-coding genes to identify the therapeutic potential for reversing drug resistance. New and more creative approaches have found the involvement of noncoding RNAs, including microRNAs and long noncoding RNAs in drug resistant sarcoma. In this review, we discuss the current knowledge of noncoding RNAs characteristics and the regulated genes involved in drug resistant sarcoma, and focus on their therapeutic potential in the future.

Keywords: drug resistance; long noncoding RNA (lncRNA); microRNA (miR); noncoding RNA (ncRNA); sarcoma

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare that they have no competing interests.

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