Display options
Cite
Abraham AC, Shah SA, Thomopoulos S. Targeting Inflammation in Rotator Cuff Tendon Degeneration and Repair. Tech Shoulder Elb Surg. 2017;18(3):84-90doi: 10.1097/BTE.0000000000000124.
Abraham, A. C., Shah, S. A., & Thomopoulos, S. (2017). Targeting Inflammation in Rotator Cuff Tendon Degeneration and Repair. Techniques in shoulder & elbow surgery, 18(3), 84-90. https://doi.org/10.1097/BTE.0000000000000124
Abraham, Adam C, et al. "Targeting Inflammation in Rotator Cuff Tendon Degeneration and Repair." Techniques in shoulder & elbow surgery vol. 18,3 (2017): 84-90. doi: https://doi.org/10.1097/BTE.0000000000000124
Abraham AC, Shah SA, Thomopoulos S. Targeting Inflammation in Rotator Cuff Tendon Degeneration and Repair. Tech Shoulder Elb Surg. 2017 Sep;18(3):84-90. doi: 10.1097/BTE.0000000000000124. PMID: 28947893; PMCID: PMC5609736.
Copy Download .nbib Format: NLM
Share it on

Tech Shoulder Elb Surg. 2017 Sep;18(3):84-90. doi: 10.1097/BTE.0000000000000124.

Targeting Inflammation in Rotator Cuff Tendon Degeneration and Repair.

Techniques in shoulder & elbow surgery

Adam C Abraham, Shivam A Shah, Stavros Thomopoulos

Affiliations

  1. Department of Orthopedic Surgery, Columbia University, Black Building 1408, 650 W 168 ST, New York, NY, 10032, USA.
  2. Department of Orthopaedic Surgery, Washington University, 660 South Euclid, Campus, Box 8233, St. Louis, MO, 63110, USA.
  3. Department of Biomedical Engineering, Columbia University, New York, NY, USA.

PMID: 28947893 PMCID: PMC5609736 DOI: 10.1097/BTE.0000000000000124

Abstract

Rotator cuff degeneration is a common affliction that results in pain and disability. Tendinopathy was historically classified with or without the involvement of the immune system. However, technological advancements in screening have shown that the immune system is both present and active in all forms of tendinopathy. During injury and healing, the coordinated effort of numerous immune cell populations work with the resident stromal cells to break down damaged tissues and stimulate remodeling. These cells deploy a wide array of tools, including phagocytosis, enzyme secretion, and chemotactic gradients to direct these processes. Yet, there remains a knowledge gap in our understanding of the sequence of critical events and regulatory factors that mediate this is process in injury and healing. Furthermore, current treatments do not specifically target inflammation at the molecular level. Typical regimens include non-steroidal anti-inflammatory drugs or corticosteroids; however, researchers have found irrevocable functional deficits following treatment, and have disputed their long-term efficacy. Therefore, developing therapeutics that specifically consider the nuances of the immune system are necessary to improve patient outcomes.

Keywords: Cytokine; Enthesis; Immune; Tendinopathy

References

  1. J Biomech. 2008;41(4):884-9 - PubMed
  2. Arthritis Rheum. 2007 Mar;56(3):871-81 - PubMed
  3. J Shoulder Elbow Surg. 2016 Feb;25(2):174-9 - PubMed
  4. Rheumatology (Oxford). 2013 May;52(5):769-79 - PubMed
  5. Br J Sports Med. 2008 Sep;42(9):753-7 - PubMed
  6. J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1:S4-9 - PubMed
  7. Genes Dev. 2012 Feb 1;26(3):203-34 - PubMed
  8. J Shoulder Elbow Surg. 2010 Apr;19(3):384-91 - PubMed
  9. JAMA. 2010 Jan 13;303(2):144-9 - PubMed
  10. Mol Med Rep. 2015 Sep;12(3):4389-95 - PubMed
  11. J Shoulder Elbow Surg. 2011 Sep;20(6):917-27 - PubMed
  12. Orthopedics. 2012 Aug 1;35(8):e1238-44 - PubMed
  13. Annu Rev Immunol. 2002;20:197-216 - PubMed
  14. J Cell Biochem. 2006 Aug 1;98(5):1076-84 - PubMed
  15. Am J Sports Med. 2010 Feb;38(2):308-17 - PubMed
  16. Future Cardiol. 2009 Nov;5(6):605-17 - PubMed
  17. J Shoulder Elbow Surg. 2001 May-Jun;10 (3):199-203 - PubMed
  18. J Shoulder Elbow Surg. 2016 Jun;25(6):865-72 - PubMed
  19. J Bone Joint Surg Am. 2004 Feb;86-A(2):219-24 - PubMed
  20. Br J Sports Med. 2016 Feb;50(4):216-20 - PubMed
  21. BMJ. 2002 Mar 16;324(7338):626-7 - PubMed
  22. Nat Clin Pract Rheumatol. 2008 Feb;4(2):82-9 - PubMed
  23. Am J Sports Med. 2014 Oct;42(10 ):2435-45 - PubMed
  24. Arthroscopy. 2013 Feb;29(2):366-76 - PubMed
  25. Nat Immunol. 2011 Jul 19;12(8):715-23 - PubMed
  26. Stem Cell Res Ther. 2015 Apr 16;6:74 - PubMed
  27. Crit Rev Immunol. 2011;31(2):115-45 - PubMed
  28. Cell Res. 2011 Jan;21(1):71-85 - PubMed
  29. Nat Rev Immunol. 2011 Feb;11(2):98-107 - PubMed
  30. J Bone Joint Surg Am. 1991 Aug;73(7):982-9 - PubMed
  31. Sci Rep. 2016 Jun 06;6:27149 - PubMed
  32. Am J Sports Med. 2008 May;36(5):987-93 - PubMed
  33. BMC Musculoskelet Disord. 2014 Jan 08;15:4 - PubMed
  34. Cochrane Database Syst Rev. 2003;(1):CD004016 - PubMed
  35. J Int Med Res. 2006 Nov-Dec;34(6):624-31 - PubMed
  36. Sci Transl Med. 2015 Oct 28;7(311):311ra173 - PubMed
  37. Scand J Med Sci Sports. 2009 Jun;19(3):338-44 - PubMed
  38. Acta Orthop Belg. 2006 Dec;72(6):756-60 - PubMed
  39. Arthroscopy. 2014 May;30(5):546-54 - PubMed
  40. Arthroscopy. 2011 Oct;27(10):1351-7 - PubMed
  41. J Appl Physiol (1985). 2005 Apr;98(4):1154-62 - PubMed
  42. Sports Med. 1999 Jun;27(6):393-408 - PubMed
  43. Stem Cell Res Ther. 2016 Sep 27;7(1):144 - PubMed
  44. J Orthop Res. 2014 Jul;32(7):944-51 - PubMed
  45. J Orthop Res. 2008 Aug;26(8):1090-7 - PubMed
  46. Nat Med. 2003 Oct;9(10):1245-50 - PubMed
  47. Stem Cells. 2006 Nov;24(11):2582-91 - PubMed
  48. Nat Med. 2012 Jul 01;18(7):1069-76 - PubMed
  49. Ann Rheum Dis. 2005 Jul;64(7):1083-6 - PubMed
  50. Med J Aust. 2005 Oct 3;183(7):384-8 - PubMed
  51. J Orthop Res. 2014 Apr;32(4):500-6 - PubMed
  52. Scand J Med Sci Sports. 2013 Dec;23(6):e353-60 - PubMed
  53. J Shoulder Elbow Surg. 2013 Dec;22(12 ):1628-32 - PubMed
  54. J Shoulder Elbow Surg. 2007 Mar-Apr;16(2):181-7 - PubMed
  55. Cardiovasc Toxicol. 2006;6(2):111-30 - PubMed
  56. Clin J Sport Med. 2006 Jan;16(1):1-3 - PubMed
  57. J Shoulder Elbow Surg. 2014 Dec;23 (12 ):1772-8 - PubMed
  58. Expert Rev Med Devices. 2006 Jul;3(4):463-70 - PubMed
  59. Cell Death Dis. 2016 Jan 21;7:e2062 - PubMed
  60. Am J Sports Med. 1993 Jan-Feb;21(1):67-70 - PubMed
  61. Sports Med Arthrosc Rehabil Ther Technol. 2012 Dec 14;4(1):48 - PubMed
  62. J Orthop Res. 2014 May;32(5):645-52 - PubMed
  63. Am J Sports Med. 2007 Mar;35(3):374-83 - PubMed
  64. Cell. 2013 Dec 5;155(6):1282-95 - PubMed
  65. Arthritis Res Ther. 2013;15(6):R184 - PubMed
  66. Nat Commun. 2015 Apr 10;6:6774 - PubMed
  67. Lancet. 2010 Nov 20;376(9754):1751-67 - PubMed
  68. Ann Rheum Dis. 2014 Jan;73(1):212-8 - PubMed
  69. J Orthop Res. 2010 Aug;28(8):1071-7 - PubMed
  70. J Shoulder Elbow Surg. 2006 May-Jun;15(3):290-9 - PubMed
  71. J Orthop Res. 2003 Mar;21(2):256-64 - PubMed
  72. J Shoulder Elbow Surg. 2015 Feb;24(2):e31-5 - PubMed
  73. J Orthop Res. 2017 Apr;35(4):894-901 - PubMed
  74. J Orthop Res. 2002 Nov;20(6):1372-9 - PubMed
  75. Am J Sports Med. 2010 Oct;38(10):2085-91 - PubMed
  76. J Orthop Res. 2016 Apr;34(4):616-22 - PubMed
  77. J Bone Joint Surg Am. 2010 Nov 17;92 (16):2623-33 - PubMed
  78. J Bone Joint Surg Am. 2013 Nov 20;95(22):1993-2000 - PubMed
  79. Am J Sports Med. 1976 Jul-Aug;4(4):145-50 - PubMed
  80. J Bone Joint Surg Am. 2001 Jul;83-A(7):1052-6 - PubMed
  81. Br J Sports Med. 1988 Jun;22(2):64-5 - PubMed
  82. J Shoulder Elbow Surg. 2014 Feb;23 (2):227-35 - PubMed
  83. J Shoulder Elbow Surg. 2016 Jun;25(6):989-97 - PubMed
  84. Bull Hosp Jt Dis. 1995;54(1):30-1 - PubMed
  85. J Shoulder Elbow Surg. 1999 Jul-Aug;8(4):296-9 - PubMed
  86. J Bone Joint Surg Am. 2006 Sep;88(9):2027-34 - PubMed
  87. Clin Orthop Relat Res. 2003 Oct;(415):111-20 - PubMed
  88. Br J Sports Med. 2014 Nov;48(21):1553-7 - PubMed
  89. Arthroscopy. 2005 Sep;21(9):1076.e1-1076.e9 - PubMed
  90. J Orthop Res. 2005 Nov;23(6):1425-32 - PubMed
  91. J Biomed Biotechnol. 2010;2010:520258 - PubMed
  92. J Orthop Res. 2015 Jun;33(6):832-9 - PubMed
  93. Int J Clin Exp Pathol. 2015 May 01;8(5):5709-14 - PubMed
  94. Genes Dev. 2004 Sep 15;18(18):2195-224 - PubMed
  95. J Orthop Res. 2017 Feb;35(2):269-280 - PubMed

Publication Types

Grant support