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Zhou D, Chen L, Yang K, et al. SOCS molecules: the growing players in macrophage polarization and function. Oncotarget. 2017;8(36):60710-60722doi: 10.18632/oncotarget.19940.
Zhou, D., Chen, L., Yang, K., Jiang, H., Xu, W., & Luan, J. (2017). SOCS molecules: the growing players in macrophage polarization and function. Oncotarget, 8(36), 60710-60722. https://doi.org/10.18632/oncotarget.19940
Zhou, Dexi, et al. "SOCS molecules: the growing players in macrophage polarization and function." Oncotarget vol. 8,36 (2017): 60710-60722. doi: https://doi.org/10.18632/oncotarget.19940
Zhou D, Chen L, Yang K, Jiang H, Xu W, Luan J. SOCS molecules: the growing players in macrophage polarization and function. Oncotarget. 2017 Aug 04;8(36):60710-60722. doi: 10.18632/oncotarget.19940. eCollection 2017 Sep 01. PMID: 28948005; PMCID: PMC5601173.
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Oncotarget. 2017 Aug 04;8(36):60710-60722. doi: 10.18632/oncotarget.19940. eCollection 2017 Sep 01.

SOCS molecules: the growing players in macrophage polarization and function.

Oncotarget

Dexi Zhou, Lu Chen, Kui Yang, Hui Jiang, Wenke Xu, Jiajie Luan

Affiliations

  1. Department of Pharmacy, Yijishan Hospital, Wannan Medical College, Wuhu, Anhui Province, China.
  2. Laboratory of Clinical Pharmacy, Wannan Medical College, Wuhu, Anhui Province, China.

PMID: 28948005 PMCID: PMC5601173 DOI: 10.18632/oncotarget.19940

Abstract

The concept of macrophage polarization is defined in terms of macrophage phenotypic heterogeneity and functional diversity. Cytokines signals are thought to be required for the polarization of macrophage populations toward different phenotypes at different stages in development, homeostasis and disease. The suppressors of cytokine signaling family of proteins contribute to the magnitude and duration of cytokines signaling, which ultimately control the subtle adjustment of the balance between divergent macrophage phenotypes. This review highlights the specific roles and mechanisms of various cytokines family and their negative regulators link to the macrophage polarization programs. Eventually, breakthrough in the identification of these molecules will provide the novel therapeutic approaches for a host of diseases by targeting macrophage phenotypic shift.

Keywords: cytokines signaling; macrophage polarization; suppressors of cytokine signaling

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no conflicts of interest.

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