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Hansel NN, Paulin LM, Gassett AJ, et al. Design of the Subpopulations and Intermediate Outcome Measures in COPD (SPIROMICS) AIR Study. BMJ Open Respir Res. 2017;4(1):e000186doi: 10.1136/bmjresp-2017-000186.
Hansel, N. N., Paulin, L. M., Gassett, A. J., Peng, R. D., Alexis, N., Fan, V. S., Bleecker, E., Bowler, R., Comellas, A. P., Dransfield, M., Han, M. K., Kim, V., Krishnan, J. A., Pirozzi, C., Cooper, C. B., Martinez, F., Woodruff, P. G., Breysse, P. J., Barr, R. G., & Kaufman, J. D. (2017). Design of the Subpopulations and Intermediate Outcome Measures in COPD (SPIROMICS) AIR Study. BMJ open respiratory research, 4(1), e000186. https://doi.org/10.1136/bmjresp-2017-000186
Hansel, Nadia N, et al. "Design of the Subpopulations and Intermediate Outcome Measures in COPD (SPIROMICS) AIR Study." BMJ open respiratory research vol. 4,1 (2017): e000186. doi: https://doi.org/10.1136/bmjresp-2017-000186
Hansel NN, Paulin LM, Gassett AJ, Peng RD, Alexis N, Fan VS, Bleecker E, Bowler R, Comellas AP, Dransfield M, Han MK, Kim V, Krishnan JA, Pirozzi C, Cooper CB, Martinez F, Woodruff PG, Breysse PJ, Barr RG, Kaufman JD. Design of the Subpopulations and Intermediate Outcome Measures in COPD (SPIROMICS) AIR Study. BMJ Open Respir Res. 2017 May 18;4(1):e000186. doi: 10.1136/bmjresp-2017-000186. eCollection 2017. PMID: 28948026; PMCID: PMC5595208.
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BMJ Open Respir Res. 2017 May 18;4(1):e000186. doi: 10.1136/bmjresp-2017-000186. eCollection 2017.

Design of the Subpopulations and Intermediate Outcome Measures in COPD (SPIROMICS) AIR Study.

BMJ open respiratory research

Nadia N Hansel, Laura M Paulin, Amanda J Gassett, Roger D Peng, Neil Alexis, Vincent S Fan, Eugene Bleecker, Russell Bowler, Alejandro P Comellas, Mark Dransfield, MeiLan K Han, Victor Kim, Jerry A Krishnan, Cheryl Pirozzi, Christopher B Cooper, Fernando Martinez, Prescott G Woodruff, Patrick J Breysse, R Graham Barr, Joel D Kaufman

Affiliations

  1. Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  2. University of Washington, Seattle, Washington, USA.
  3. Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
  4. University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
  5. VA Puget Sound Health Care System, Seattle, Washington, USA.
  6. Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
  7. National Jewish Health, Denver, Colorado, USA.
  8. University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
  9. University of Alabama at Birmingham, Birmingham, Alabama, USA.
  10. University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
  11. Temple University School of Medicine, Philadelphia, Pennsylvania, USA.
  12. University of Illinois, Chicago, Illinois, USA.
  13. University of Utah Health Sciences Center, Salt Lake City, Utah, USA.
  14. University of California Los Angeles, Los Angeles, California, USA.
  15. Weill Medical College, New York City, New York, USA.
  16. University of California San Francisco School of Medicine, San Francisco, California, USA.
  17. National Center for Environmental Health/Agency for Toxic Substances & Disease Registry, Atlanta, Georgia, USA.
  18. Columbia University Medicine Center, New York, USA.

PMID: 28948026 PMCID: PMC5595208 DOI: 10.1136/bmjresp-2017-000186

Abstract

INTRODUCTION: Population-based epidemiological evidence suggests that exposure to ambient air pollutants increases hospitalisations and mortality from chronic obstructive pulmonary disease (COPD), but less is known about the impact of exposure to air pollutants on patient-reported outcomes, morbidity and progression of COPD.

METHODS AND ANALYSIS: The Subpopulations and Intermediate Outcome Measures in COPD (SPIROMICS) Air Pollution Study (SPIROMICS AIR) was initiated in 2013 to investigate the relation between individual-level estimates of short-term and long-term air pollution exposures, day-to-day symptom variability and disease progression in individuals with COPD. SPIROMICS AIR builds on a multicentre study of smokers with COPD, supplementing it with state-of-the-art air pollution exposure assessments of fine particulate matter, oxides of nitrogen, ozone, sulfur dioxide and black carbon. In the parent study, approximately 3000 smokers with and without airflow obstruction are being followed for up to 3 years for the identification of intermediate biomarkers which predict disease progression. Subcohorts undergo daily symptom monitoring using comprehensive daily diaries. The air monitoring and modelling methods employed in SPIROMICS AIR will provide estimates of individual exposure that incorporate residence-specific infiltration characteristics and participant-specific time-activity patterns. The overarching study aim is to understand the health effects of short-term and long-term exposures to air pollution on COPD morbidity, including exacerbation risk, patient-reported outcomes and disease progression.

ETHICS AND DISSEMINATION: The institutional review boards of all the participating institutions approved the study protocols. The results of the trial will be presented at national and international meetings and published in peer-reviewed journals.

Keywords: COPD epidemiology; emphysema

Conflict of interest statement

Competing interests: All authors have completed the ICMJE uniform disclosure form at www.icmje.org/coi_disclosure.pdf and declare: NNH has research grants from NIH/NIEHS and EPA, research grants and p

References

  1. Environmetrics. 2009 Sep 1;21(6):606-631 - PubMed
  2. Thorax. 2001 Dec;56(12):932-4 - PubMed
  3. Epidemiology. 2012 Jul;23(4):607-15 - PubMed
  4. Am J Respir Crit Care Med. 2013 May 15;187(10):1085-90 - PubMed
  5. Am J Respir Crit Care Med. 2008 Feb 15;177(4):396-401 - PubMed
  6. Epidemiology. 1996 Jan;7(1):20-8 - PubMed
  7. Eur Respir J. 2009 Sep;34(3):648-54 - PubMed
  8. Am J Respir Crit Care Med. 2002 Jul 1;166(1):111-7 - PubMed
  9. J Expo Sci Environ Epidemiol. 2006 May;16(3):238-41 - PubMed
  10. Environ Health Perspect. 2012 Jun;120(6):824-30 - PubMed
  11. Sci Total Environ. 2005 Jun 1;345(1-3):23-30 - PubMed
  12. Thorax. 1999 Jul;54(7):581-6 - PubMed
  13. Am Rev Respir Dis. 1992 Jun;145(6):1321-7 - PubMed
  14. JAMA. 2006 Mar 8;295(10):1127-34 - PubMed
  15. J Glob Health. 2015 Dec;5(2):020415 - PubMed
  16. COPD. 2016 Jun;13(3):372-9 - PubMed
  17. Environ Health. 2012 Oct 05;11:75 - PubMed
  18. Thorax. 2011 Jul;66(7):591-6 - PubMed
  19. J Expo Sci Environ Epidemiol. 2013 May-Jun;23(3):223-31 - PubMed
  20. Am J Respir Crit Care Med. 2011 Feb 15;183(4):455-61 - PubMed
  21. J Expo Sci Environ Epidemiol. 2016 Jun;26(4):349-55 - PubMed
  22. Environ Res. 2016 Oct;150:398-402 - PubMed
  23. Am J Respir Crit Care Med. 1995 Sep;152(3):1107-36 - PubMed
  24. J Expo Anal Environ Epidemiol. 2001 May-Jun;11(3):231-52 - PubMed
  25. Environ Sci Technol. 2009 Jul 1;43(13):4687-93 - PubMed
  26. Elife. 2015 Oct 05;4:e09623 - PubMed
  27. Am J Respir Crit Care Med. 2007 Sep 1;176(5):465-72 - PubMed
  28. Thorax. 2007 Sep;62(9):780-5 - PubMed
  29. Am J Respir Crit Care Med. 1997 Jan;155(1):122-9 - PubMed
  30. Occup Environ Med. 2010 Jan;67(1):2-10 - PubMed
  31. Am J Respir Crit Care Med. 2016 Oct 1;194(7):794-806 - PubMed
  32. Am Rev Respir Dis. 1993 Jun;147(6 Pt 1):1336-40 - PubMed
  33. Am J Epidemiol. 2007 Feb 15;165(4):435-43 - PubMed
  34. Occup Environ Med. 2010 Aug;67(8):556-61 - PubMed
  35. Am J Respir Crit Care Med. 2011 Feb 1;183(3):323-9 - PubMed
  36. Thorax. 2012 Mar;67(3):238-43 - PubMed
  37. Environ Health Perspect. 2015 Apr;123(4):301-9 - PubMed
  38. Environ Health Perspect. 2015 Feb;123(2):144-51 - PubMed
  39. Eur Respir J. 2001 May;17(5):1024-33 - PubMed
  40. BMC Public Health. 2007 Mar 16;7:37 - PubMed

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