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Milani M, Sparavigna A. The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and . Clin Cosmet Investig Dermatol. 2017;10:311-315doi: 10.2147/CCID.S144180.
Milani, M., & Sparavigna, A. (2017). The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and . Clinical, cosmetic and investigational dermatology, 10311-315. https://doi.org/10.2147/CCID.S144180
Milani, Massimo, and Sparavigna, Adele. "The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and ." Clinical, cosmetic and investigational dermatology vol. 10 (2017): 311-315. doi: https://doi.org/10.2147/CCID.S144180
Milani M, Sparavigna A. The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and . Clin Cosmet Investig Dermatol. 2017 Aug 11;10:311-315. doi: 10.2147/CCID.S144180. eCollection 2017. PMID: 28860834; PMCID: PMC5560567.
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Clin Cosmet Investig Dermatol. 2017 Aug 11;10:311-315. doi: 10.2147/CCID.S144180. eCollection 2017.

The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and .

Clinical, cosmetic and investigational dermatology

Massimo Milani, Adele Sparavigna

Affiliations

  1. Difa Cooper, Caronno Pertusella, Varese.
  2. Dermatologic Institute Dermig Milan, Milan, Italy.

PMID: 28860834 PMCID: PMC5560567 DOI: 10.2147/CCID.S144180

Abstract

INTRODUCTION: Moisturizing products are commonly used to improve hydration in skin dryness conditions. However, some topical hydrating products could have negative effects on skin barrier function. In addition, hydrating effects of moisturizers are not commonly evaluated up to 24 hours after a single application. Hyaluronic acid (HA) and glycerin are very well-known substances able to improve skin hydration.

STUDY AIM: To evaluate and compare the 24-hour effects of JCS fluid on skin hydration and on transepidermal water loss (TEWL) in healthy subjects in comparison with the control site.

SUBJECTS AND METHODS: Twenty healthy women, mean age 40 years, were enrolled in an intra-subject (right vs left), randomized, assessor-blinded, controlled, 1-day trial. The primary end points were the skin hydration and TEWL, evaluated at the volar surface of the forearm and in standardized conditions (temperature- and humidity-controlled room: 23°C and 30% of humidity) using a corneometer and a vapometer device at baseline, 1, 8 and 24 hours after JCS fluid application. Measurements were performed by an operator blinded for the treatments.

RESULTS: Skin hydration after 24 hours was significantly higher (

CONCLUSION: A single application of JCS significantly improves skin hydration for up to 24 hours at the same time as improving skin barrier function.

Keywords: Centella asiatica stem cells; hyaluronic acid; moisturizing; randomized controlled trial

Conflict of interest statement

Disclosure MM is the medical director of Difa Cooper, an Industrial Farmaceutica Cantabria group company that commercializes the tested product. AS is the head of research of Dermig Institute. She rec

References

  1. Dermatol Ther. 2004;17 Suppl 1:43-8 - PubMed
  2. Int J Dermatol. 1994 Feb;33(2):119-22 - PubMed
  3. Expert Opin Drug Deliv. 2017 Mar 20;:1-15 - PubMed
  4. J Invest Dermatol. 1998 Jan;110(1):20-3 - PubMed
  5. J Drugs Dermatol. 2011 Sep;10(9):990-1000 - PubMed
  6. Yonsei Med J. 2006 Jun 30;47(3):293-306 - PubMed
  7. Biomaterials. 2006 Nov;27(33):5689-97 - PubMed
  8. J Biol Chem. 2007 Feb 23;282(8):5597-607 - PubMed
  9. Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7360-5 - PubMed
  10. Curr Opin Pediatr. 2009 Aug;21(4):486-90 - PubMed
  11. J Invest Dermatol. 1988 Mar;90(3):412-4 - PubMed
  12. J Cosmet Dermatol. 2007 Jun;6(2):75-82 - PubMed
  13. Contact Dermatitis. 1990 Mar;22(3):164-78 - PubMed
  14. Int J Cosmet Sci. 2000 Feb;22(1):21-52 - PubMed
  15. Pharm Biol. 2013 Sep;51(9):1182-7 - PubMed
  16. J Cosmet Laser Ther. 2015;17(6):343-52 - PubMed
  17. Ital J Biochem. 1988 Mar-Apr;37(2):69-77 - PubMed
  18. J Postgrad Med. 2001 Jan-Mar;47(1):45-50 - PubMed
  19. Wound Repair Regen. 1999 Mar-Apr;7(2):79-89 - PubMed
  20. J Cell Biol. 1993 Jul;122(1):257-64 - PubMed
  21. Skin Pharmacol Physiol. 2004 Sep-Oct;17(5):207-13 - PubMed
  22. Dermatoendocrinol. 2012 Jul 1;4(3):253-8 - PubMed
  23. Int J Dermatol. 1996 Aug;35(8):539-44 - PubMed
  24. Arthritis Rheum. 1988 Jan;31(1):63-71 - PubMed
  25. Skin Therapy Lett. 2005 Jun;10(5):1-8 - PubMed
  26. J Eur Acad Dermatol Venereol. 2009 Nov;23(11):1267-72 - PubMed

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