Front Endocrinol (Lausanne). 2017 Aug 15;8:203. doi: 10.3389/fendo.2017.00203. eCollection 2017.
Diabetic Neuropathy Evaluated by a Novel Device: Sural Nerve Conduction Is Associated with Glycemic Control and Ankle-Brachial Pressure Index in Japanese Patients with Diabetes.
Frontiers in endocrinology
Hidetaka Hamasaki, Yasuteru Hamasaki
Affiliations
Affiliations
- Hamasaki Clinic, Kagoshima, Japan.
PMID: 28861044
PMCID: PMC5559425 DOI: 10.3389/fendo.2017.00203
Abstract
BACKGROUND: Currently, no international diagnostic criteria for diabetic neuropathy (DN) have been established. Recently, a novel point-of-care sural nerve conduction device has been developed. We aimed to investigate associations between DN and clinical parameters related to the development and progression of DN by using this novel device.
METHODS: We conducted a retrospective observational study in patients with diabetes whose sural nerve functions were measured using DPN Check between January 2015 and October 2016. Multiple and logistic regression analyses were conducted to assess the associations of sural nerve conduction velocity (SNCV) and amplitude (SNAP) with clinical parameters related to DN.
RESULTS: A total of 740 patients were enrolled in this study. At baseline, 211 patients were diagnosed with DN by using DPN Check. The sensitivity, specificity, and positive likelihood ratio of DPN Check compared with ankle reflex as reference were 81%, 46%, and 1.5, respectively. Of these, 182 patients were followed up for approximately 1 year to measure changes in SNCV and SNAP. Both SNCV and SNAP were inversely associated with duration of diabetes, plasma glucose levels, and hemoglobin A1c levels at baseline, whereas these were positively associated with ankle-brachial index. Logistic regression analysis revealed that poor glycemic control was associated with increased risk of reduction in both SNCV [odds ratio = 1.570; 95% confidence interval (CI) = 1.298-1.898;
CONCLUSION: Sural nerve functions were significantly associated with glycemic control and arteriosclerosis in patients with diabetes. DPN Check may be useful as a screening tool to identify DN in clinical practice.
Keywords: amplitude; diabetic neuropathy; glycemic control; nerve conduction velocity; sural nerve
References
- PLoS One. 2014 Jan 22;9(1):e86515 - PubMed
- Arch Intern Med. 2006 Oct 9;166(18):1986-92 - PubMed
- Diabetes Res Clin Pract. 1995 May;28(2):103-17 - PubMed
- Neurology. 2005 Jan 25;64(2):199-207 - PubMed
- Curr Diab Rep. 2014;14(9):528 - PubMed
- Diabetes Res Clin Pract. 2015 Aug;109(2):397-403 - PubMed
- Diabetes Care. 1997 Jul;20(7):1162-7 - PubMed
- Neural Regen Res. 2014 Jul 15;9(14):1389-94 - PubMed
- N Engl J Med. 2003 Jan 30;348(5):383-93 - PubMed
- Nat Clin Pract Neurol. 2007 Jun;3(6):331-40 - PubMed
- Diabetes Res Clin Pract. 2007 Sep;77 Suppl 1:S184-9 - PubMed
- Lancet. 1998 Sep 12;352(9131):837-53 - PubMed
- Am Rev Respir Dis. 1963 May;87:684-93 - PubMed
- Arch Med Sci. 2016 Apr 1;12(2):390-3 - PubMed
- N Engl J Med. 2009 Jan 8;360(2):129-39 - PubMed
- N Engl J Med. 2005 Jan 27;352(4):341-50 - PubMed
- Diabetes Care. 2011 Jul;34(7):1642-7 - PubMed
- Diabetes Care. 2015 May;38(5):793-800 - PubMed
- Ann Neurol. 1995 Dec;38(6):869-80 - PubMed
- J Neurol Neurosurg Psychiatry. 2016 Dec;87(12 ):1336-1342 - PubMed
- Diabetes Metab Res Rev. 2011 Oct;27(7):620-8 - PubMed
- Diabet Med. 2016 Nov;33(11):1466-1476 - PubMed
- Clin Interv Aging. 2016 Mar 15;11:313-8 - PubMed
- Diabetes Res Clin Pract. 2007 Sep;77 Suppl 1:S178-83 - PubMed
- J Diabetes Complications. 2015 Nov-Dec;29(8):1066-70 - PubMed
- Endocrine. 2016 Sep;53(3):643-8 - PubMed
- Diabetes Care. 2010 Oct;33(10):2285-93 - PubMed
- Diabetes. 1997 Apr;46(4):665-70 - PubMed
- Diabetes Care. 2014;37(1):31-8 - PubMed
- Lancet. 2010 Aug 7;376(9739):419-30 - PubMed
- N Engl J Med. 1993 Sep 30;329(14 ):977-86 - PubMed
- J Peripher Nerv Syst. 2009 Dec;14(4):257-67 - PubMed
- Diabetologia. 2015 Sep;58(9):2161-8 - PubMed
- J Diabetes Complications. 2013 Sep-Oct;27(5):436-42 - PubMed
- Rev Diabet Stud. 2015 Spring-Summer;12 (1-2):48-62 - PubMed
- Curr Med Chem. 2007;14(16):1703-12 - PubMed
Publication Types