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Nin F, Yoshida T, Murakami S, et al. Computer modeling defines the system driving a constant current crucial for homeostasis in the mammalian cochlea by integrating unique ion transports. NPJ Syst Biol Appl. 2017;3:24doi: 10.1038/s41540-017-0025-0.
Nin, F., Yoshida, T., Murakami, S., Ogata, G., Uetsuka, S., Choi, S., Doi, K., Sawamura, S., Inohara, H., Komune, S., Kurachi, Y., & Hibino, H. (2017). Computer modeling defines the system driving a constant current crucial for homeostasis in the mammalian cochlea by integrating unique ion transports. NPJ systems biology and applications, 324. https://doi.org/10.1038/s41540-017-0025-0
Nin, Fumiaki, et al. "Computer modeling defines the system driving a constant current crucial for homeostasis in the mammalian cochlea by integrating unique ion transports." NPJ systems biology and applications vol. 3 (2017): 24. doi: https://doi.org/10.1038/s41540-017-0025-0
Nin F, Yoshida T, Murakami S, Ogata G, Uetsuka S, Choi S, Doi K, Sawamura S, Inohara H, Komune S, Kurachi Y, Hibino H. Computer modeling defines the system driving a constant current crucial for homeostasis in the mammalian cochlea by integrating unique ion transports. NPJ Syst Biol Appl. 2017 Aug 25;3:24. doi: 10.1038/s41540-017-0025-0. eCollection 2017. PMID: 28861279; PMCID: PMC5572463.
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NPJ Syst Biol Appl. 2017 Aug 25;3:24. doi: 10.1038/s41540-017-0025-0. eCollection 2017.

Computer modeling defines the system driving a constant current crucial for homeostasis in the mammalian cochlea by integrating unique ion transports.

NPJ systems biology and applications

Fumiaki Nin, Takamasa Yoshida, Shingo Murakami, Genki Ogata, Satoru Uetsuka, Samuel Choi, Katsumi Doi, Seishiro Sawamura, Hidenori Inohara, Shizuo Komune, Yoshihisa Kurachi, Hiroshi Hibino

Affiliations

  1. Department of Molecular Physiology, Niigata University School of Medicine, Niigata, Japan.
  2. Center for Transdisciplinary Research, Niigata University, Niigata, Japan.
  3. AMED-CREST, AMED, Niigata, Japan.
  4. Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  5. Department of Physiology, School of Medicine, Toho University, Tokyo, Japan.
  6. Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medicine, Osaka University, Suita, Japan.
  7. Department of Electrical and Electronics Engineering, Niigata University, Niigata, Japan.
  8. Department of Otolaryngology, Faculty of Medicine, Kindai University, Osakasayama, Japan.
  9. Division of Otolaryngology-Head and Neck Surgery, Yuaikai Oda Hospital, Kashima, Japan.
  10. Division of Molecular and Cellular Pharmacology, Department of Pharmacology, Graduate School of Medicine, Osaka University, Suita, Japan.
  11. The Global Center for Medical Engineering and Informatics, Osaka University, Suita, Japan.

PMID: 28861279 PMCID: PMC5572463 DOI: 10.1038/s41540-017-0025-0

Abstract

The cochlear lateral wall-an epithelial-like tissue comprising inner and outer layers-maintains +80 mV in endolymph. This endocochlear potential supports hearing and represents the sum of all membrane potentials across apical and basolateral surfaces of both layers. The apical surfaces are governed by K

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