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Ren MW, Du Y, Ren S, et al. Epstein-Barr virus-encoded small RNAs in idiopathic orbital inflammatory pseudotumor tissues: a comparative case series. Int J Ophthalmol. 2017;10(8):1268-1272doi: 10.18240/ijo.2017.08.14.
Ren, M. W., Du, Y., Ren, S., Tang, C. Y., & He, J. F. (2017). Epstein-Barr virus-encoded small RNAs in idiopathic orbital inflammatory pseudotumor tissues: a comparative case series. International journal of ophthalmology, 10(8), 1268-1272. https://doi.org/10.18240/ijo.2017.08.14
Ren, Min-Wei, et al. "Epstein-Barr virus-encoded small RNAs in idiopathic orbital inflammatory pseudotumor tissues: a comparative case series." International journal of ophthalmology vol. 10,8 (2017): 1268-1272. doi: https://doi.org/10.18240/ijo.2017.08.14
Ren MW, Du Y, Ren S, Tang CY, He JF. Epstein-Barr virus-encoded small RNAs in idiopathic orbital inflammatory pseudotumor tissues: a comparative case series. Int J Ophthalmol. 2017 Aug 18;10(8):1268-1272. doi: 10.18240/ijo.2017.08.14. eCollection 2017. PMID: 28861354; PMCID: PMC5554847.
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Int J Ophthalmol. 2017 Aug 18;10(8):1268-1272. doi: 10.18240/ijo.2017.08.14. eCollection 2017.

Epstein-Barr virus-encoded small RNAs in idiopathic orbital inflammatory pseudotumor tissues: a comparative case series.

International journal of ophthalmology

Min-Wei Ren, Yi Du, Shan Ren, Cheng-Ye Tang, Jian-Feng He

Affiliations

  1. Department of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
  2. Department of Ophthalmology, Liuzhou People's Hospital, Liuzhou 545006, Guangxi Zhuang Autonomous Region, China.

PMID: 28861354 PMCID: PMC5554847 DOI: 10.18240/ijo.2017.08.14

Abstract

AIM: To investigate the positive rate and types of cells that express Epstein-Barr virus-encoded small RNAs (EBERs) and to determine the distribution of EBER-expressing cells in idiopathic orbital inflammatory pseudotumor (IOIP) tissues.

METHODS: We retrospectively examined 40 archived paraffin specimens from two teaching hospitals in Southern China between January 2007 and January 2015 that were pathologically determined to exhibit IOIP. Eleven concurrent paraffin specimens of thyroid-associated ophthalmopathy (TAO) composed the control group.

RESULTS: The positive expression rate of EBERs was 47.5% (19/40) in the IOIP group, which was significantly higher than that in the TAO group [0 (0/11),

CONCLUSION: The positive rate, types, and distribution of EBER-expressing cells in IOIP have been documented. These findings are conducive for a better understanding of the underlying mechanisms of Epstein-Barr virus infection in IOIP pathogenesis.

Keywords: Epstein-Barr virus; Epstein-Barr virus-encoded small RNAs; Graves' ophthalmopathy; idiopathic orbital inflammatory disease; thyroid eye disease

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