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Council N, Dyce J, Drost WT, et al. Bilateral patellar fractures and increased cortical bone thickness associated with long-term oral alendronate treatment in a cat. JFMS Open Rep. 2017;3(2):2055116917727137doi: 10.1177/2055116917727137.
Council, N., Dyce, J., Drost, W. T., de Brito Galvao, J. F., Rosol, T. J., & Chew, D. J. (2017). Bilateral patellar fractures and increased cortical bone thickness associated with long-term oral alendronate treatment in a cat. JFMS open reports, 3(2), 2055116917727137. https://doi.org/10.1177/2055116917727137
Council, Nicola, et al. "Bilateral patellar fractures and increased cortical bone thickness associated with long-term oral alendronate treatment in a cat." JFMS open reports vol. 3,2 (2017): 2055116917727137. doi: https://doi.org/10.1177/2055116917727137
Council N, Dyce J, Drost WT, de Brito Galvao JF, Rosol TJ, Chew DJ. Bilateral patellar fractures and increased cortical bone thickness associated with long-term oral alendronate treatment in a cat. JFMS Open Rep. 2017 Aug 29;3(2):2055116917727137. doi: 10.1177/2055116917727137. eCollection 2017. PMID: 28890795; PMCID: PMC5580850.
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JFMS Open Rep. 2017 Aug 29;3(2):2055116917727137. doi: 10.1177/2055116917727137. eCollection 2017.

Bilateral patellar fractures and increased cortical bone thickness associated with long-term oral alendronate treatment in a cat.

JFMS open reports

Nicola Council, Jon Dyce, Wm Tod Drost, Joao Felipe de Brito Galvao, Thomas J Rosol, Dennis J Chew

Affiliations

  1. Hillside Animal Hospital, Scottsdale, AZ, USA.
  2. Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
  3. VCA Arboretum View Animal Hospital, Downers Grove, IL, USA.
  4. Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.

PMID: 28890795 PMCID: PMC5580850 DOI: 10.1177/2055116917727137

Abstract

CASE SUMMARY: A 14-year-old cat presented with bilateral patellar fractures and radiographically thickened tibial cortices. This cat had been treated with alendronate for 8 years prior to presentation. To remove the subjectivity of the radiographic evaluation, tibial radiographs from 35 apparently healthy geriatric cats were used for comparison. Cortical and diaphyseal thickness were measured at the proximal and distal thirds of the tibia. Our cat had increased cortical bone thickness compared to that of the control cats.

RELEVANCE AND NOVEL INFORMATION: Treatment with bisphosphonates can lead to brittle bones and fractures after prolonged use in humans. This is the first description of fractures and cortical bone changes that may have been associated with prolonged bisphosphonate use in a cat. Radiographic measurements of cortical bone thickness may identify cats that are at increased risk for bone pathology secondary to prolonged alendronate use.

Conflict of interest statement

Conflict of interest: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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