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Seu KG, Papoin J, Fessler R, et al. Unraveling Macrophage Heterogeneity in Erythroblastic Islands. Front Immunol. 2017;8:1140doi: 10.3389/fimmu.2017.01140.
Seu, K. G., Papoin, J., Fessler, R., Hom, J., Huang, G., Mohandas, N., Blanc, L., & Kalfa, T. A. (2017). Unraveling Macrophage Heterogeneity in Erythroblastic Islands. Frontiers in immunology, 81140. https://doi.org/10.3389/fimmu.2017.01140
Seu, Katie Giger, et al. "Unraveling Macrophage Heterogeneity in Erythroblastic Islands." Frontiers in immunology vol. 8 (2017): 1140. doi: https://doi.org/10.3389/fimmu.2017.01140
Seu KG, Papoin J, Fessler R, Hom J, Huang G, Mohandas N, Blanc L, Kalfa TA. Unraveling Macrophage Heterogeneity in Erythroblastic Islands. Front Immunol. 2017 Sep 20;8:1140. doi: 10.3389/fimmu.2017.01140. eCollection 2017. PMID: 28979259; PMCID: PMC5611421.
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Front Immunol. 2017 Sep 20;8:1140. doi: 10.3389/fimmu.2017.01140. eCollection 2017.

Unraveling Macrophage Heterogeneity in Erythroblastic Islands.

Frontiers in immunology

Katie Giger Seu, Julien Papoin, Rose Fessler, Jimmy Hom, Gang Huang, Narla Mohandas, Lionel Blanc, Theodosia A Kalfa

Affiliations

  1. Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
  2. Laboratory of Developmental Erythropoiesis, Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, Manhasset, NY, United States.
  3. Department of Molecular Medicine and Pediatrics, Hofstra-Northwell School of Medicine, Hempstead, NY, United States.
  4. Red Cell Physiology Laboratory, Lindsey F Kimball Research Institute, New York Blood Center, New York, NY, United States.

PMID: 28979259 PMCID: PMC5611421 DOI: 10.3389/fimmu.2017.01140

Abstract

Mammalian erythropoiesis occurs within erythroblastic islands (EBIs), niches where maturing erythroblasts interact closely with a central macrophage. While it is generally accepted that EBI macrophages play an important role in erythropoiesis, thorough investigation of the mechanisms by which they support erythropoiesis is limited largely by inability to identify and isolate the specific macrophage sub-population that constitute the EBI. Early studies utilized immunohistochemistry or immunofluorescence to study EBI morphology and structure, while more recent efforts have used flow cytometry for high-throughput quantitative characterization of EBIs and their central macrophages. However, these approaches based on the expectation that EBI macrophages are a homogeneous population (F4/80

Keywords: CD11b; CD163; CD169; VCAM-1; erythroblastic islands; erythropoiesis; imaging flow cytometry; macrophages

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