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Ibsen MS, Connor M, Glass M. Cannabinoid CB. Cannabis Cannabinoid Res. 2017;2(1):48-60doi: 10.1089/can.2016.0037.
Ibsen, M. S., Connor, M., & Glass, M. (2017). Cannabinoid CB. Cannabis and cannabinoid research, 2(1), 48-60. https://doi.org/10.1089/can.2016.0037
Ibsen, Mikkel Søes, et al. "Cannabinoid CB." Cannabis and cannabinoid research vol. 2,1 (2017): 48-60. doi: https://doi.org/10.1089/can.2016.0037
Ibsen MS, Connor M, Glass M. Cannabinoid CB. Cannabis Cannabinoid Res. 2017 Mar 01;2(1):48-60. doi: 10.1089/can.2016.0037. eCollection 2017. PMID: 28861504; PMCID: PMC5436336.
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Cannabis Cannabinoid Res. 2017 Mar 01;2(1):48-60. doi: 10.1089/can.2016.0037. eCollection 2017.

Cannabinoid CB.

Cannabis and cannabinoid research

Mikkel Søes Ibsen, Mark Connor, Michelle Glass

Affiliations

  1. Department of Pharmacology, School of Medical Sciences, University of Auckland, Auckland, New Zealand.
  2. Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, 2 Technology Place, Macquarie University, New South Wales, Australia.

PMID: 28861504 PMCID: PMC5436336 DOI: 10.1089/can.2016.0037

Abstract

An agonist that acts through a single receptor can activate numerous signaling pathways. Recent studies have suggested that different ligands can differentially activate these pathways by stabilizing a limited range of receptor conformations, which in turn preferentially drive different downstream signaling cascades. This concept, termed "biased signaling" represents an exciting therapeutic opportunity to target specific pathways that elicit only desired effects, while avoiding undesired effects mediated by different signaling cascades. The cannabinoid receptors CB

Keywords: G protein-coupled receptor; agonist bias; cannabinoid receptors; functional selectivity

Conflict of interest statement

No competing financial interests exist.

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