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Tatham KC, O'Dea KP, Wakabayashi K, et al. The role of ex vivo lung perfusion in lung transplantation. J Intensive Care Soc. 2014;16(1):58-63doi: 10.1177/1751143714554062.
Tatham, K. C., O'Dea, K. P., Wakabayashi, K., Marczin, N., & Takata, M. (2015). The role of ex vivo lung perfusion in lung transplantation. Journal of the Intensive Care Society, 16(1), 58-63. https://doi.org/10.1177/1751143714554062
Tatham, Kate Colette, et al. "The role of ex vivo lung perfusion in lung transplantation." Journal of the Intensive Care Society vol. 16,1 (2015): 58-63. doi: https://doi.org/10.1177/1751143714554062
Tatham KC, O'Dea KP, Wakabayashi K, Marczin N, Takata M. The role of ex vivo lung perfusion in lung transplantation. J Intensive Care Soc. 2015 Feb;16(1):58-63. doi: 10.1177/1751143714554062. Epub 2014 Dec 09. PMID: 28979376; PMCID: PMC5593288.
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J Intensive Care Soc. 2015 Feb;16(1):58-63. doi: 10.1177/1751143714554062. Epub 2014 Dec 09.

The role of ex vivo lung perfusion in lung transplantation.

Journal of the Intensive Care Society

Kate Colette Tatham, Kieran Patrick O'Dea, Kenji Wakabayashi, Nandor Marczin, Masao Takata

Affiliations

  1. Section of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Chelsea and Westminster Hospital NHS Foundation Trust, Imperial College, London, UK.
  2. Office for Global Education and Career Development, International Exchange Centre, Tokyo Medical and Dental University, Tokyo, Japan.
  3. Department of Anaesthetics, The Royal Brompton and Harefield NHS Foundation Trust, Imperial College, London, UK.

PMID: 28979376 PMCID: PMC5593288 DOI: 10.1177/1751143714554062

Abstract

Whilst lung transplantation is a viable solution for end-stage lung disease, donor shortages, donor lung inflammation and perioperative lung injury remain major limitations. Ex vivo lung perfusion has emerged as the next frontier in lung transplantation to address and overcome these limitations, with multicentre clinical trials ongoing in the UK, rest of Europe and North America. Our research seeks to identify the poorly understood cellular and molecular mechanisms of primary graft dysfunction through the development of an isolated perfused lung model of transplantation and investigation of the role of pulmonary inflammation in this paradigm.

Keywords: EVLP; Lung transplantation; ischaemia-reperfusion

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