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Lane AS, Champion B, Orde S, et al. Diabetic ketoacidosis due to fulminant type 1 diabetes: A rare subtype of type 1 diabetes leading to unusual sequelae. J Intensive Care Soc. 2014;16(1):64-70doi: 10.1177/1751143714551249.
Lane, A. S., Champion, B., Orde, S., & Dravec, D. (2015). Diabetic ketoacidosis due to fulminant type 1 diabetes: A rare subtype of type 1 diabetes leading to unusual sequelae. Journal of the Intensive Care Society, 16(1), 64-70. https://doi.org/10.1177/1751143714551249
Lane, Andrew S, et al. "Diabetic ketoacidosis due to fulminant type 1 diabetes: A rare subtype of type 1 diabetes leading to unusual sequelae." Journal of the Intensive Care Society vol. 16,1 (2015): 64-70. doi: https://doi.org/10.1177/1751143714551249
Lane AS, Champion B, Orde S, Dravec D. Diabetic ketoacidosis due to fulminant type 1 diabetes: A rare subtype of type 1 diabetes leading to unusual sequelae. J Intensive Care Soc. 2015 Feb;16(1):64-70. doi: 10.1177/1751143714551249. Epub 2014 Dec 10. PMID: 28979377; PMCID: PMC5593281.
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J Intensive Care Soc. 2015 Feb;16(1):64-70. doi: 10.1177/1751143714551249. Epub 2014 Dec 10.

Diabetic ketoacidosis due to fulminant type 1 diabetes: A rare subtype of type 1 diabetes leading to unusual sequelae.

Journal of the Intensive Care Society

Andrew S Lane, Bernard Champion, Sam Orde, Danijela Dravec

Affiliations

  1. Sydney Medical School, Sydney, NSW, Australia.
  2. Nepean Hospital, Sydney, NSW, Australia.

PMID: 28979377 PMCID: PMC5593281 DOI: 10.1177/1751143714551249

Abstract

Diabetic ketoacidosis (DKA) is a life-threatening complication of type 1 diabetes (T1D), which without treatment leads to death. Fulminant type 1 diabetes (FT1D) is a subtype characterised by a markedly rapid and almost complete destruction of pancreatic β-cells, with acute onset leading to severe metabolic derangement and commonly ICU admission. We present a case of an 18-year-old male presenting with FT1D with two rare complications of pneumomediastinum and stress-induced cardiomyopathy (SIC) with significant myocardial necrosis. We also discuss the aetiology of the pneumomediastinum; the latest thoughts on SIC: moving beyond the simple description of 'Takotsubo cardiomyopathy'; the role of troponins in critical illness; and genetic predisposition for DKA due to FT1D.

Keywords: Fulminant type 1 diabetes; Takotsubo cardiomyopathy; pneumomediastinum; stress induced cardiomyopathy; troponin

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