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Khan I, Malik R, Khan A, et al. Breast Cancer Metastases to the Gastrointestinal Tract Presenting with Anemia and Intra-abdominal Bleed. Cureus. 2017;9(7):e1429doi: 10.7759/cureus.1429.
Khan, I., Malik, R., Khan, A., Assad, S., Zahid, M., Sohail, M. S., Yasin, F., & Qavi, A. H. (2017). Breast Cancer Metastases to the Gastrointestinal Tract Presenting with Anemia and Intra-abdominal Bleed. Cureus, 9(7), e1429. https://doi.org/10.7759/cureus.1429
Khan, Idrees, et al. "Breast Cancer Metastases to the Gastrointestinal Tract Presenting with Anemia and Intra-abdominal Bleed." Cureus vol. 9,7 (2017): e1429. doi: https://doi.org/10.7759/cureus.1429
Khan I, Malik R, Khan A, Assad S, Zahid M, Sohail MS, Yasin F, Qavi AH. Breast Cancer Metastases to the Gastrointestinal Tract Presenting with Anemia and Intra-abdominal Bleed. Cureus. 2017 Jul 06;9(7):e1429. doi: 10.7759/cureus.1429. PMID: 28924517; PMCID: PMC5587403.
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Cureus. 2017 Jul 06;9(7):e1429. doi: 10.7759/cureus.1429.

Breast Cancer Metastases to the Gastrointestinal Tract Presenting with Anemia and Intra-abdominal Bleed.

Cureus

Idrees Khan, Rehan Malik, Amina Khan, Salman Assad, Mehr Zahid, Muhammad Saad Sohail, Faizan Yasin, Ahmed H Qavi

Affiliations

  1. Center for Healthcare Advancement & Outcomes Research, Baptist Health Medical Group.
  2. Internal Medicine, Mount Sinai Medical Center, Miami Beach, Florida.
  3. Shifa Tameer E Millat University, Shifa International Hospital, Islamabad, Pakistan.
  4. Department of Medicine, Shifa International Hospital, Islamabad, Pakistan.
  5. Internal Medicine, University of Lahore, Lahore, Pakistan.
  6. Shifa International Hospital, Shifa International Hospital, Islamabad, Pakistan.
  7. Department of Medicine, Shifa Tameer-e-Millat University.
  8. Department of Medicine, Mahroof Hospital.

PMID: 28924517 PMCID: PMC5587403 DOI: 10.7759/cureus.1429

Abstract

Signet ring adenocarcinoma of the breast with synchronous metastasis to the gastrointestinal (GI) tract is a rare occurrence, typically presenting with abdominal pain, dyspepsia, or GI bleed. We report a case of metastatic breast cancer presenting with a complaint of anemia. A further diagnostic evaluation revealed generalized lymphadenopathy, nodular thickening of the urinary bladder wall, bone lesions, and enlarged pancreas. Biopsies from the lymph nodes, pancreatic biopsy, and bladder nodule all revealed a signet cell carcinoma. An upper and lower GI endoscopy revealed multiple ulcerated gastric mucosal nodules and polypoid folds in the cecum and proximal ascending colon; the biopsies from these lesions were also positive for signet ring cell adenocarcinoma.

Keywords: anemia; breast cancer; case reports; gastrointestinal bleed; metastasis

Conflict of interest statement

The authors have declared that no competing interests exist.

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