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Ghofraniha L, Mirfeizi Z, Khabbaz FS, et al. Correlation of echocardiographic findings of pulmonary hypertension with six-minute walk test and plasma pro b-type natriuretic peptide level in systemic lupus erythematous. Electron Physician. 2017;9(8):5122-5128doi: 10.19082/5122.
Ghofraniha, L., Mirfeizi, Z., Khabbaz, F. S., Vakilian, F., & Eslami, S. (2017). Correlation of echocardiographic findings of pulmonary hypertension with six-minute walk test and plasma pro b-type natriuretic peptide level in systemic lupus erythematous. Electronic physician, 9(8), 5122-5128. https://doi.org/10.19082/5122
Ghofraniha, Leila, et al. "Correlation of echocardiographic findings of pulmonary hypertension with six-minute walk test and plasma pro b-type natriuretic peptide level in systemic lupus erythematous." Electronic physician vol. 9,8 (2017): 5122-5128. doi: https://doi.org/10.19082/5122
Ghofraniha L, Mirfeizi Z, Khabbaz FS, Vakilian F, Eslami S. Correlation of echocardiographic findings of pulmonary hypertension with six-minute walk test and plasma pro b-type natriuretic peptide level in systemic lupus erythematous. Electron Physician. 2017 Aug 01;9(8):5122-5128. doi: 10.19082/5122. eCollection 2017 Aug. PMID: 28979751; PMCID: PMC5614301.
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Electron Physician. 2017 Aug 01;9(8):5122-5128. doi: 10.19082/5122. eCollection 2017 Aug.

Correlation of echocardiographic findings of pulmonary hypertension with six-minute walk test and plasma pro b-type natriuretic peptide level in systemic lupus erythematous.

Electronic physician

Leila Ghofraniha, Zahra Mirfeizi, Fatemeh Seyyedi Khabbaz, Farveh Vakilian, Saeed Eslami

Affiliations

  1. Pulmonologist, Lung Disease Research Center, School of Medicine, Mashhad University of Medicine Sciences, Mashhad, Iran.
  2. MD, Associate Professor of Rheumatology, Rheumatic Diseases Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  3. Internist, Rheumatic Diseases Research Center, Preventive Atherosclerotic Research Center, Cardiology Department, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
  4. Internal Medicine, Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
  5. Department of Medical Informatics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

PMID: 28979751 PMCID: PMC5614301 DOI: 10.19082/5122

Abstract

INTRODUCTION: Pulmonary arterial hypertension (PAH) is an increasingly recognized complication of systemic lupus erythematous (SLE), which may remain undiagnosed if asymptomatic.

OBJECTIVE: This study aimed to determine the correlation between echocardiographic findings of PAH and six-minute walk test (6WMT) and serum pro b-type natriuretic peptide (proBNP) level in patients with SLE.

METHODS: This cross-sectional study was performed on 50 SLE patients selected from patients referring to the outpatient's department of the Rheumatology Clinic at Imam Reza Hospital in Mashhad, Iran, from July 2013 through September 2014, using resting transthoracic echocardiography to estimate systolic pulmonary artery pressure (sPAP). Variables were summarized as counts and/or percentages or as mean±SD. Inter-group comparisons were made performing two-tailed Fisher's exact test or Mann-Whitney U test, using SPSS 22.

RESULTS: In general, five out of fifty patients were diagnosed to have PAH with sPAP>30 mmHg (range: 31-40 mmHg) based on echocardiographic findings. Spirometric parameters did not show any differences between the two groups (p>0.05), while the difference in total distance walked during six minutes and serum proBNP level between SLE patients with and without PAH was significant (P<0.05). A high correlation was found between PAP and serum proBNP level, but not between PAP and the distance walked during six-minutes in SLE patients.

CONCLUSION: The point prevalence of PAH in SLE patients was 10%; the significant correlation between PAP and serum proBNP level suggests that it can be used as a valuable marker for early diagnosis of asymptomatic pulmonary hypertension in patients with SLE.

Keywords: Pulmonary arterial hypertension; Serum proBNP levels; Six-minute walk test; Systemic lupus erythematosus; Transthoracic echocardiography

Conflict of interest statement

Conflict of Interest: There is no conflict of interest to be declared.

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