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Am J Cancer Res. 2017 Sep 01;7(9):1959-1970. eCollection 2017.

Inverse association of rab31 and mucin-1 (CA15-3) antigen levels in estrogen receptor-positive (ER+) breast cancer tissues with clinicopathological parameters and patients' prognosis.

American journal of cancer research

Matthias Kotzsch, Thomas Kirchner, Susanne Soelch, Sonja Schäfer, Katrin Friedrich, Gustavo Baretton, Viktor Magdolen, Thomas Luther

Affiliations

  1. Medizinisches Labor OstsachsenD-02526 Bautzen, Germany.
  2. Institut für Pathologie, Technische Universität DresdenD-01307 Dresden, Germany.
  3. Klinische Forschergruppe, Klinik für Frauenheilkunde und Geburtshilfe, Technische Universität MünchenD-81675 München, Germany.

PMID: 28979817 PMCID: PMC5622229

Abstract

Dysregulated expression of rab31, a member of the large Rab protein family of the Ras superfamily of small GTPases, has been observed in several types of cancer, including breast cancer. Rab31, depending on its expression level, may regulate the switch between an invasive versus proliferative phenotype of breast cancer cells

Keywords: CA15-3; Rab31; antigen levels; breast cancer; mucin-1; prognosis; tumour tissue extracts

Conflict of interest statement

None.

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