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Duffey OJ, Smart N. Approaches to augment vascularisation and regeneration of the adult heart via the reactivated epicardium. Glob Cardiol Sci Pract. 2016;2016(4):e201628doi: 10.21542/gcsp.2016.28.
Duffey, O. J., & Smart, N. (2016). Approaches to augment vascularisation and regeneration of the adult heart via the reactivated epicardium. Global cardiology science & practice, 2016(4), e201628. https://doi.org/10.21542/gcsp.2016.28
Duffey, Owen J, and Smart, Nicola. "Approaches to augment vascularisation and regeneration of the adult heart via the reactivated epicardium." Global cardiology science & practice vol. 2016,4 (2016): e201628. doi: https://doi.org/10.21542/gcsp.2016.28
Duffey OJ, Smart N. Approaches to augment vascularisation and regeneration of the adult heart via the reactivated epicardium. Glob Cardiol Sci Pract. 2016 Dec 30;2016(4):e201628. doi: 10.21542/gcsp.2016.28. PMID: 28979901; PMCID: PMC5624183.
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Glob Cardiol Sci Pract. 2016 Dec 30;2016(4):e201628. doi: 10.21542/gcsp.2016.28.

Approaches to augment vascularisation and regeneration of the adult heart via the reactivated epicardium.

Global cardiology science & practice

Owen J Duffey, Nicola Smart

Affiliations

  1. Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

PMID: 28979901 PMCID: PMC5624183 DOI: 10.21542/gcsp.2016.28

Abstract

Survival rates following myocardial infarction have increased in recent years but current treatments for post-infarction recovery are inadequate and cannot induce regeneration of damaged hearts. Regenerative medicine could provide disease-reversing treatments by harnessing modern concepts in cell and developmental biology. A recently-established paradigm in regenerative medicine is that regeneration of a tissue can be achieved by reactivation of the coordinated developmental processes that originally formed the tissue. In the heart, the epicardium has emerged as an important regulator of cardiac development and reactivation of epicardial developmental processes may provide a means to enable cardiac regeneration. Indeed, in adult mouse hearts, treatment with thymosin β4 and other drug-like molecules reactivates the epicardium and improves outcomes after myocardial infarction by inducing regenerative paracrine signalling, neovascularisation and

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