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Hassan M, Philip P. CANHEART: Is HDL cholesterol a cardiovascular specific risk factor?. Glob Cardiol Sci Pract. 2016;2016(4):e201634doi: 10.21542/gcsp.2016.34.
Hassan, M., & Philip, P. (2016). CANHEART: Is HDL cholesterol a cardiovascular specific risk factor?. Global cardiology science & practice, 2016(4), e201634. https://doi.org/10.21542/gcsp.2016.34
Hassan, Mohamed, and Philip, Peter. "CANHEART: Is HDL cholesterol a cardiovascular specific risk factor?." Global cardiology science & practice vol. 2016,4 (2016): e201634. doi: https://doi.org/10.21542/gcsp.2016.34
Hassan M, Philip P. CANHEART: Is HDL cholesterol a cardiovascular specific risk factor?. Glob Cardiol Sci Pract. 2016 Dec 30;2016(4):e201634. doi: 10.21542/gcsp.2016.34. PMID: 28979903; PMCID: PMC5624186.
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Glob Cardiol Sci Pract. 2016 Dec 30;2016(4):e201634. doi: 10.21542/gcsp.2016.34.

CANHEART: Is HDL cholesterol a cardiovascular specific risk factor?.

Global cardiology science & practice

Mohamed Hassan, Peter Philip

Affiliations

  1. Division of Cardiology, Aswan Heart Centre, Aswan, Egypt.

PMID: 28979903 PMCID: PMC5624186 DOI: 10.21542/gcsp.2016.34

Abstract

Initial observational studies have identified high-density lipoprotein cholesterol (HDL-C) as an independent predictor of cardiovascular (CV) risk, even in patients on optimal statin therapy. However, the notion that higher HDL-C is better, has been seriously challenged by the results from several recent clinical and genetic trials. Data from the CANHEART study serve to clarify the relation between HDL-C and cause-specific mortality. Individuals with lower HDL-C levels were independently associated with higher risk of CV, cancer, and non-CV/non-cancer mortality compared with individuals in the reference ranges of HDL-C levels. Given the similarities in associations between HDL-C and CV as swell as non-CV outcomes, it is likely that HDL-C level serve as a marker of risk rather than a causal CV specific risk factor.

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