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ACS Cent Sci. 2017 Sep 27;3(9):1026-1031. doi: 10.1021/acscentsci.7b00311. Epub 2017 Sep 13.

Virus-like Particle Display of the α-Gal Carbohydrate for Vaccination against .

ACS central science

Anna Paula V Moura, Luiza C B Santos, Carlos Ramon Nascimento Brito, Edward Valencia, Caroline Junqueira, Adalberto A P Filho, Mauricio R V Sant'Anna, Nelder F Gontijo, Daniella C Bartholomeu, Ricardo T Fujiwara, Ricardo T Gazzinelli, Craig S McKay, Carlos A Sanhueza, M G Finn, Alexandre Ferreira Marques

Affiliations

  1. Instituto de Ciencias Biologicas, Departamento de Parasitologia, Universidade Federal de Minas Gerais, Pampulha, Belo Horizonte, Minas Gerais, Brazil.
  2. Instituto de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil.
  3. School of Chemistry and Biochemistry, School of Biology, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.

PMID: 28979944 PMCID: PMC5620979 DOI: 10.1021/acscentsci.7b00311

Abstract

Secreted and surface-displayed carbohydrates are essential for virulence and viability of many parasites, including for immune system evasion. We have identified the α-Gal trisaccharide epitope on the surface of the protozoan parasites

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