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Yamamoto S, Ono M, Yuba E, et al. In Vitro Sonodynamic Therapeutic Effect of Polyion Complex Micelles Incorporating Titanium Dioxide Nanoparticles. Nanomaterials (Basel). 2017;7(9)doi: 10.3390/nano7090268.
Yamamoto, S., Ono, M., Yuba, E., & Harada, A. (2017). In Vitro Sonodynamic Therapeutic Effect of Polyion Complex Micelles Incorporating Titanium Dioxide Nanoparticles. Nanomaterials (Basel, Switzerland), 7(9), . https://doi.org/10.3390/nano7090268
Yamamoto, Satoshi, et al. "In Vitro Sonodynamic Therapeutic Effect of Polyion Complex Micelles Incorporating Titanium Dioxide Nanoparticles." Nanomaterials (Basel, Switzerland) vol. 7,9 (2017). doi: https://doi.org/10.3390/nano7090268
Yamamoto S, Ono M, Yuba E, Harada A. In Vitro Sonodynamic Therapeutic Effect of Polyion Complex Micelles Incorporating Titanium Dioxide Nanoparticles. Nanomaterials (Basel). 2017 Sep 11;7(9). doi: 10.3390/nano7090268. PMID: 28891984; PMCID: PMC5618379.
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Nanomaterials (Basel). 2017 Sep 11;7(9). doi: 10.3390/nano7090268.

In Vitro Sonodynamic Therapeutic Effect of Polyion Complex Micelles Incorporating Titanium Dioxide Nanoparticles.

Nanomaterials (Basel, Switzerland)

Satoshi Yamamoto, Masafumi Ono, Eiji Yuba, Atsushi Harada

Affiliations

  1. Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan. [email protected].
  2. Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan. [email protected].
  3. Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan. [email protected].
  4. Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan. [email protected].

PMID: 28891984 PMCID: PMC5618379 DOI: 10.3390/nano7090268

Abstract

Titanium dioxide nanoparticles (TiO₂ NPs) can act as sonosensitizers, generating reactive oxygen species under ultrasound irradiation, for use in sonodynamic therapy. For TiO₂ NPs delivery, we prepared polyion complex micelles incorporating TiO₂ NPs (TiO₂ NPs-PIC micelles) by mixing TiO₂ NPs with polyallylamine bearing poly(ethylene glycol) grafts. In this study, the effects of polymer composition and ultrasound irradiation conditions on the sonodynamic therapeutic effect toward HeLa cells were evaluated experimentally using cell viability evaluation, intracellular distribution observation, and a cell staining assay. TiO₂ NPs-PIC micelles with widely distributed features induced a significant decrease in cell viability under ultrasound irradiation. Furthermore, prolonging the irradiation time killed cells more effectively than did increasing the ultrasound power. The combination of TiO₂ NP-PIC micelles and ultrasound irradiation was confirmed to induce apoptotic cell death.

Keywords: Titanium dioxide nanoparticles; polyion complex micelles; sonodynamic therapy

Conflict of interest statement

The authors declare no conflicts of interest.

References

  1. J Control Release. 2011 Jan 20;149(2):190-5 - PubMed
  2. J Colloid Interface Sci. 2006 Apr 15;296(2):565-71 - PubMed
  3. Ultrason Sonochem. 2011 Sep;18(5):1197-204 - PubMed
  4. Environ Sci Technol. 2010 Mar 15;44(6):1962-7 - PubMed
  5. Nature. 1972 Jul 7;238(5358):37-8 - PubMed
  6. Cancer Res. 1992 Apr 15;52(8):2346-8 - PubMed
  7. Chem Soc Rev. 2006 Feb;35(2):180-96 - PubMed
  8. Photochem Photobiol. 2006 Sep-Oct;82(5):1178-86 - PubMed
  9. Ultrason Sonochem. 2007 Feb;14(2):184-90 - PubMed
  10. Apoptosis. 2000 Nov;5(5):415-8 - PubMed
  11. Biomacromolecules. 2011 Oct 10;12(10):3353-68 - PubMed
  12. Environ Sci Technol. 2009 Mar 1;43(5):1354-9 - PubMed
  13. Ultrason Sonochem. 2012 May;19(3):607-14 - PubMed

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