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Baldassarre A, Felli C, Prantera G, et al. Circulating microRNAs and Bioinformatics Tools to Discover Novel Diagnostic Biomarkers of Pediatric Diseases. Genes (Basel). 2017;8(9)doi: 10.3390/genes8090234.
Baldassarre, A., Felli, C., Prantera, G., & Masotti, A. (2017). Circulating microRNAs and Bioinformatics Tools to Discover Novel Diagnostic Biomarkers of Pediatric Diseases. Genes, 8(9), . https://doi.org/10.3390/genes8090234
Baldassarre, Antonella, et al. "Circulating microRNAs and Bioinformatics Tools to Discover Novel Diagnostic Biomarkers of Pediatric Diseases." Genes vol. 8,9 (2017). doi: https://doi.org/10.3390/genes8090234
Baldassarre A, Felli C, Prantera G, Masotti A. Circulating microRNAs and Bioinformatics Tools to Discover Novel Diagnostic Biomarkers of Pediatric Diseases. Genes (Basel). 2017 Sep 19;8(9). doi: 10.3390/genes8090234. PMID: 28925938; PMCID: PMC5615367.
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Genes (Basel). 2017 Sep 19;8(9). doi: 10.3390/genes8090234.

Circulating microRNAs and Bioinformatics Tools to Discover Novel Diagnostic Biomarkers of Pediatric Diseases.

Genes

Antonella Baldassarre, Cristina Felli, Giorgio Prantera, Andrea Masotti

Affiliations

  1. Bambino Gesù Children's Hospital-IRCCS, Research Laboratories, 00146 Rome, Italy. [email protected].
  2. Bambino Gesù Children's Hospital-IRCCS, Research Laboratories, 00146 Rome, Italy. [email protected].
  3. Department of Ecology and Biology, Università della Tuscia, 01100 Viterbo, Italy. [email protected].
  4. Bambino Gesù Children's Hospital-IRCCS, Research Laboratories, 00146 Rome, Italy. [email protected].

PMID: 28925938 PMCID: PMC5615367 DOI: 10.3390/genes8090234

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the post-transcriptional level. Current studies have shown that miRNAs are also present in extracellular spaces, packaged into various membrane-bound vesicles, or associated with RNA-binding proteins. Circulating miRNAs are highly stable and can act as intercellular messengers to affect many physiological processes. MicroRNAs circulating in body fluids have generated strong interest in their potential use as clinical biomarkers. In fact, their remarkable stability and the relative ease of detection make circulating miRNAs ideal tools for rapid and non-invasive diagnosis. This review summarizes recent insights about the origin, functions and diagnostic potential of extracellular miRNAs by especially focusing on pediatric diseases in order to explore the feasibility of alternative sampling sources for the development of non-invasive pediatric diagnostics. We will also discuss specific bioinformatics tools and databases for circulating miRNAs focused on the identification and discovery of novel diagnostic biomarkers of pediatric diseases.

Keywords: bioinformatics tools; biomarkers; body fluids; circulating microRNAs; pediatric diseases

Conflict of interest statement

The authors declare no conflict of interest.

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