Display options
Share it on

Asian Pac J Cancer Prev. 2017 Sep 27;18(9):2339-2343. doi: 10.22034/APJCP.2017.18.9.2339.

Cervical Cancer Prevention Through HPV Vaccination in Low- and Middle-Income Countries in Asia.

Asian Pacific journal of cancer prevention : APJCP

Zheng Quan Toh, Paul V Licciardi, Fiona M Russell, Suzanne M Garland, Tsetsegsaikhan Batmunkh, Edward K Mulholland

Affiliations

  1. Pneumococcal Research, Murdoch Children’s Research Institute, Royal Children’s Hospital, Parkville, Victoria, Australia. Email: [email protected]

PMID: 28950675 PMCID: PMC5720633 DOI: 10.22034/APJCP.2017.18.9.2339

Abstract

Cervical cancer is ranked the first or second most common cancer in women of low- and middle-income countries (LMICs) in Asia. Cervical cancer is almost exclusively caused by human papillomavirus (HPV), and majority of the cases can be prevented with the use of HPV vaccines. The HPV vaccines have demonstrated high vaccine efficacies against HPV infection and cervical cancer precursors in clinical and post-marketing studies, and are in use in most high-income countries. However, their use in LMICs are limited mainly due to the high costs and logistics in delivering multiple doses of the vaccine. Other issues such as the safety of the vaccines, social and cultural factors, as well as poor knowledge and awareness of the virus have also contributed to the low uptake of the vaccine. This mini-review focuses on the need for HPV vaccine implementation in Asia given the substantial disease burden and underuse of HPV vaccines in LMICs in this region. In addition, the progress towards HPV vaccine introduction, and barriers preventing further rollout of these essential, life-saving vaccines are also discussed in this article.

Creative Commons Attribution License

Keywords: HPV vaccine; low- and middle-income countries; cervical cancer

References

  1. N Engl J Med. 2015 Feb 19;372(8):711-23 - PubMed
  2. Nat Rev Clin Oncol. 2016 Feb;13(2):119-32 - PubMed
  3. Am J Prev Med. 2012 Jan;42(1):44-52 - PubMed
  4. Vaccine. 2006 Aug 31;24 Suppl 3:S3/71-7 - PubMed
  5. Vaccine. 2015 Jul 17;33(31):3726-30 - PubMed
  6. BMC Public Health. 2015 Dec 18;15:1257 - PubMed
  7. Public Health Rep. 2016 Jan-Feb;131(1):17-25 - PubMed
  8. Papillomavirus Res. 2016 Dec;2:9-10 - PubMed
  9. Braz J Infect Dis. 2014 Nov-Dec;18(6):651-9 - PubMed
  10. Womens Health Issues. 2012 Nov-Dec;22(6):e571-9 - PubMed
  11. PLoS One. 2013 May 23;8(5):e63476 - PubMed
  12. Vaccine. 2015 Apr 8;33(15):1786-90 - PubMed
  13. Sex Transm Infect. 2006 Jun;82 Suppl 3:iii3-9 - PubMed
  14. Vaccine. 2013 Aug 20;31(37):3786-804 - PubMed
  15. Lancet Oncol. 2012 Jan;13(1):89-99 - PubMed
  16. Int J STD AIDS. 2015 Oct;26(12):893-902 - PubMed
  17. J Adolesc Health. 2010 Apr;46(4):379-84 - PubMed
  18. BMJ. 2010 Jul 20;341:c3493 - PubMed
  19. Drug Saf. 2013 Jun;36(6):393-412 - PubMed
  20. Lancet. 2009 Jul 25;374(9686):301-14 - PubMed
  21. N Engl J Med. 2007 May 10;356(19):1915-27 - PubMed
  22. Clin Infect Dis. 2012 Apr;54(7):1026-34 - PubMed
  23. PLoS One. 2014 Mar 11;9(3):e90912 - PubMed
  24. Bull World Health Organ. 2011 Nov 1;89(11):821-830B - PubMed
  25. Med J Aust. 2013 Nov 4;199(9):614-7 - PubMed
  26. Sex Health. 2013 May;10(2):171-8 - PubMed
  27. Clin Infect Dis. 2016 Aug 15;63(4):519-27 - PubMed

Publication Types