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Naghshtabrizi B, Borzouei S, Bigvand P, et al. Evaluation of the Relationship between Serum 25-Hydroxy Vitamin D and Hypertension in Hamadan, Iran-A Case Control Study. J Clin Diagn Res. 2017;11(7):LC01-LC03doi: 10.7860/JCDR/2017/25522.10187.
Naghshtabrizi, B., Borzouei, S., Bigvand, P., & Seifrabiei, M. A. (2017). Evaluation of the Relationship between Serum 25-Hydroxy Vitamin D and Hypertension in Hamadan, Iran-A Case Control Study. Journal of clinical and diagnostic research : JCDR, 11(7), LC01-LC03. https://doi.org/10.7860/JCDR/2017/25522.10187
Naghshtabrizi, Behshad, et al. "Evaluation of the Relationship between Serum 25-Hydroxy Vitamin D and Hypertension in Hamadan, Iran-A Case Control Study." Journal of clinical and diagnostic research : JCDR vol. 11,7 (2017): LC01-LC03. doi: https://doi.org/10.7860/JCDR/2017/25522.10187
Naghshtabrizi B, Borzouei S, Bigvand P, Seifrabiei MA. Evaluation of the Relationship between Serum 25-Hydroxy Vitamin D and Hypertension in Hamadan, Iran-A Case Control Study. J Clin Diagn Res. 2017 Jul;11(7):LC01-LC03. doi: 10.7860/JCDR/2017/25522.10187. Epub 2017 Jul 01. PMID: 28892933; PMCID: PMC5583848.
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J Clin Diagn Res. 2017 Jul;11(7):LC01-LC03. doi: 10.7860/JCDR/2017/25522.10187. Epub 2017 Jul 01.

Evaluation of the Relationship between Serum 25-Hydroxy Vitamin D and Hypertension in Hamadan, Iran-A Case Control Study.

Journal of clinical and diagnostic research : JCDR

Behshad Naghshtabrizi, Shiva Borzouei, Pedram Bigvand, Mohamad Ali Seifrabiei

Affiliations

  1. Associate Professor, Department of Cardiology, Hamadan Medical School, Hamadan University of Medical Sciences, Hamadan, Iran.
  2. Assistant Professor, Department of Internal Medicine, Hamadan Medical School, Hamadan University of Medical Sciences, Hamadan, Iran.
  3. Junior Resident, Department of Internal Medicine, Babol Medical School, Babol University of Medical Sciences, Babol, Mazandaran, Iran.
  4. Associate Professor, Department of Community Medicine, Hamadan Medical School, Hamadan University of Medical Sciences, Hamadan, Iran.

PMID: 28892933 PMCID: PMC5583848 DOI: 10.7860/JCDR/2017/25522.10187

Abstract

INTRODUCTION: Hypertension or high blood pressure is one of the main reasons of fatality in the world. The role of vitamin D in developing hypertension has not been proved yet. Some studies have shown positive correlation between low serum vitamin D level and hypertension. Due to this fact, recognising hypertension risk factors such as potential impact of low serum vitamin D level seems to be required.

AIM: This study was conducted to evaluate potential impact of serum vitamin D level on hypertension.

MATERIALS AND METHODS: This case-control study had 188 subjects including 55 cases suffering from hypertension and 133 controls with normal blood pressure in Hamadan, Iran. After taking the medical history and physical examination, 5 cc of their blood was taken to measure their serum 25-Hydroxyvitamin D [25(OH)D] level through ELISA test. Data analysis was done by version 16.0 of SPSS software and used independent sample t-test and Chi-square test for related comparisons.

RESULTS: Mean and standard deviation of serum 25(OH)D level in patients suffering from hypertension was 13.10±9.7 ng/ml and in control group was 20.87±10.34 ng/ml. This variance was statistically significant (p<0.001). Mean serum 25(OH)D level in both case and control groups was measured after gender and age stratification. Mean serum 25(OH)D level in cases and controls was 13.12±11.4 ng/ml and 21.38±11.47 ng/ml in males (p=0.016) and 13.10±9.91 ng/ml and 19.19±10.55 ng/ml (p=0.004) in females, respectively. Mean serum 25(OH)D level in under 50-year-old was 10.82±8.73 ng/ml and 20.07±11.17 ng/ml in cases and controls respectively (p<0.001). In over 50-year-old, there was no significant relationship between mean serum 25(OH)D and blood pressure levels (p>0.05).

CONCLUSION: According to this study, reverse relationship between serum 25(OH)D and blood pressure levels was seen.

Keywords: High blood pressure; Risk factor; Vitamin deficiency

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