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Khalili MR, Jahadi HR, Karimi M, et al. Corneal Collagen Cross-linking for Treatment of Bacterial and Herpetic Keratitis. J Clin Diagn Res. 2017;11(7):NC12-NC16doi: 10.7860/JCDR/2017/24863.10253.
Khalili, M. R., Jahadi, H. R., Karimi, M., & Yasemi, M. (2017). Corneal Collagen Cross-linking for Treatment of Bacterial and Herpetic Keratitis. Journal of clinical and diagnostic research : JCDR, 11(7), NC12-NC16. https://doi.org/10.7860/JCDR/2017/24863.10253
Khalili, Mohammad Reza, et al. "Corneal Collagen Cross-linking for Treatment of Bacterial and Herpetic Keratitis." Journal of clinical and diagnostic research : JCDR vol. 11,7 (2017): NC12-NC16. doi: https://doi.org/10.7860/JCDR/2017/24863.10253
Khalili MR, Jahadi HR, Karimi M, Yasemi M. Corneal Collagen Cross-linking for Treatment of Bacterial and Herpetic Keratitis. J Clin Diagn Res. 2017 Jul;11(7):NC12-NC16. doi: 10.7860/JCDR/2017/24863.10253. Epub 2017 Jul 01. PMID: 28892949; PMCID: PMC5583818.
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J Clin Diagn Res. 2017 Jul;11(7):NC12-NC16. doi: 10.7860/JCDR/2017/24863.10253. Epub 2017 Jul 01.

Corneal Collagen Cross-linking for Treatment of Bacterial and Herpetic Keratitis.

Journal of clinical and diagnostic research : JCDR

Mohammad Reza Khalili, Hamid Reza Jahadi, Mashaallah Karimi, Masoud Yasemi

Affiliations

  1. Assistant Professor, Department of Ophthalmology, Poostchi Ophthalmology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Fars, Iran.
  2. Professor, Department of Ophthalmology, Poostchi Ophthalmology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Fars, Iran.
  3. Ophthalmologist, Department of Ophthalmology, Poostchi Ophthalmology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Fars, Iran.

PMID: 28892949 PMCID: PMC5583818 DOI: 10.7860/JCDR/2017/24863.10253

Abstract

INTRODUCTION: Optimal management of infective keratitis is a formidable challenge and subject of ongoing studies. Recently, Collagen Cross-Linking (CXL) of the cornea has been considered to be a new effective therapeutic approach for resistant infectious keratitis.

AIM: Aim of the study was to evaluate the effectiveness of CXL with Ultraviolet-A (UV-A) and riboflavin for treatment of the refractory bacterial and Herpes Simplex Virus (HSV) keratitis.

MATERIALS AND METHODS: In this prospective interventional study, eight patients with diagnosis of infectious keratitis who were referred to Khalili Hospital eye emergency room, between 2014 and 2015 were included in the study. There were six patients with bacterial keratitis and two patients with HSV keratitis; they were resistant to conventional treatment and underwent CXL. Response to the treatment was considered as good if rapid epithelialization and rapid decrease in stromal infiltration occurred.

RESULTS: Microbial culture in the bacterial keratitis group showed coagulase negative

CONCLUSION: Although, CXL seems promising in the treatment of patients with refractory bacterial keratitis, but in some cases, it is ineffective. CXL may be an alternative treatment for refractory cases of HSV keratitis but recurrence is possible.

Keywords: Herpes simplex virus; Infectious keratitis; Keratoplasty

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