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Sindhwani G, Arora M, Thakker VD, et al. MRI in Chemotherapy induced Leukoencephalopathy: Report of Two Cases and Radiologist's Perspective. J Clin Diagn Res. 2017;11(7):TD08-TD09doi: 10.7860/JCDR/2017/29164.10248.
Sindhwani, G., Arora, M., Thakker, V. D., & Jain, A. (2017). MRI in Chemotherapy induced Leukoencephalopathy: Report of Two Cases and Radiologist's Perspective. Journal of clinical and diagnostic research : JCDR, 11(7), TD08-TD09. https://doi.org/10.7860/JCDR/2017/29164.10248
Sindhwani, Geetika, et al. "MRI in Chemotherapy induced Leukoencephalopathy: Report of Two Cases and Radiologist's Perspective." Journal of clinical and diagnostic research : JCDR vol. 11,7 (2017): TD08-TD09. doi: https://doi.org/10.7860/JCDR/2017/29164.10248
Sindhwani G, Arora M, Thakker VD, Jain A. MRI in Chemotherapy induced Leukoencephalopathy: Report of Two Cases and Radiologist's Perspective. J Clin Diagn Res. 2017 Jul;11(7):TD08-TD09. doi: 10.7860/JCDR/2017/29164.10248. Epub 2017 Jul 01. PMID: 28893007; PMCID: PMC5583911.
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J Clin Diagn Res. 2017 Jul;11(7):TD08-TD09. doi: 10.7860/JCDR/2017/29164.10248. Epub 2017 Jul 01.

MRI in Chemotherapy induced Leukoencephalopathy: Report of Two Cases and Radiologist's Perspective.

Journal of clinical and diagnostic research : JCDR

Geetika Sindhwani, Manali Arora, Vishal Dhirenbhai Thakker, Abhinav Jain

Affiliations

  1. Assistant Professor, Department of Radiodiagnosis, Pramukhswami Medical College and Shree Krishna Hospital, Anand, Gujarat, India.
  2. Senior Resident, Department of Radiodiagnosis, Pramukhswami Medical College and Shree Krishna Hospital, Anand, Gujarat, India.
  3. Resident, Department of Urology, Muljibhai Patel Urological Hospital, Nadiad, Gujarat, India.

PMID: 28893007 PMCID: PMC5583911 DOI: 10.7860/JCDR/2017/29164.10248

Abstract

Leukoencephalopathy is a progressive white matter disease primarily caused due to myelin damage by a variety of factors. Chemotherapy for oncological treatment is an uncommon but important cause of potentially reversible leukoencephalopathy. In current radiological setting, conventional and diffusion weighted MRI play a significant role in early and accurate detection of this entity. We are hereby presenting MRI evaluation of two cases of methotrexate and 5-fluorouracil induced toxic leukoencephalopathy.

Keywords: Diffusion weighted imaging; Methotrexate; Neurotoxicity; Toxic encephalopathy

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