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Suryadevara V, Lankapalli SR, Danda LH, et al. Studies on jackfruit seed starch as a novel natural superdisintegrant for the design and evaluation of irbesartan fast dissolving tablets. Integr Med Res. 2017;6(3):280-291doi: 10.1016/j.imr.2017.04.001.
Suryadevara, V., Lankapalli, S. R., Danda, L. H., Pendyala, V., & Katta, V. (2017). Studies on jackfruit seed starch as a novel natural superdisintegrant for the design and evaluation of irbesartan fast dissolving tablets. Integrative medicine research, 6(3), 280-291. https://doi.org/10.1016/j.imr.2017.04.001
Suryadevara, Vidyadhara, et al. "Studies on jackfruit seed starch as a novel natural superdisintegrant for the design and evaluation of irbesartan fast dissolving tablets." Integrative medicine research vol. 6,3 (2017): 280-291. doi: https://doi.org/10.1016/j.imr.2017.04.001
Suryadevara V, Lankapalli SR, Danda LH, Pendyala V, Katta V. Studies on jackfruit seed starch as a novel natural superdisintegrant for the design and evaluation of irbesartan fast dissolving tablets. Integr Med Res. 2017 Sep;6(3):280-291. doi: 10.1016/j.imr.2017.04.001. Epub 2017 May 26. PMID: 28951842; PMCID: PMC5605381.
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Integr Med Res. 2017 Sep;6(3):280-291. doi: 10.1016/j.imr.2017.04.001. Epub 2017 May 26.

Studies on jackfruit seed starch as a novel natural superdisintegrant for the design and evaluation of irbesartan fast dissolving tablets.

Integrative medicine research

Vidyadhara Suryadevara, Sasidhar Reddyvallam Lankapalli, Lakshmi Harika Danda, Vijetha Pendyala, Vijetha Katta

Affiliations

  1. Department of Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Guntur, India.

PMID: 28951842 PMCID: PMC5605381 DOI: 10.1016/j.imr.2017.04.001

Abstract

BACKGROUND: In the present investigation, an attempt was made to isolate starch from jackfruit seed powder and utilize it as a superdisintegrant to design fast dissolving tablets of irbesartan.

METHODS: Starch was isolated from jackfruit seeds via aqueous and alkali extraction processes and evaluated for its physicochemical properties, for phytochemical tests, and for acute toxicity studies. Irbesartan fast dissolving formulations were prepared using the wet granulation technique.

RESULTS: Acute toxicity studies for the extract indicated that all rats were healthy with no physiological changes in their behavior. The prepared irbesartan tablet formulations were found to be stable according to the Indian Pharmacopoeia-specified limits for postcompression parameters. From

CONCLUSION: The tablets prepared from jackfruit seed starch as superdisintegrant were found to be suitable for preparation of fast dissolving tablets.

Keywords: fast dissolving tablets; irbesartan; jackfruit seeds; superdisintegrants

References

  1. Drug Dev Ind Pharm. 2004 May;30(5):525-34 - PubMed
  2. Chem Pharm Bull (Tokyo). 1996 Nov;44(11):2121-7 - PubMed
  3. J Clin Pharmacol. 1998 Aug;38(8):702-7 - PubMed

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