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Aduba DC, Yang H. Polysaccharide Fabrication Platforms and Biocompatibility Assessment as Candidate Wound Dressing Materials. Bioengineering (Basel). 2017;4(1)doi: 10.3390/bioengineering4010001.
Aduba, D. C., & Yang, H. (2017). Polysaccharide Fabrication Platforms and Biocompatibility Assessment as Candidate Wound Dressing Materials. Bioengineering (Basel, Switzerland), 4(1), . https://doi.org/10.3390/bioengineering4010001
Aduba, Donald C, and Yang, Hu. "Polysaccharide Fabrication Platforms and Biocompatibility Assessment as Candidate Wound Dressing Materials." Bioengineering (Basel, Switzerland) vol. 4,1 (2017). doi: https://doi.org/10.3390/bioengineering4010001
Aduba DC, Yang H. Polysaccharide Fabrication Platforms and Biocompatibility Assessment as Candidate Wound Dressing Materials. Bioengineering (Basel). 2017 Jan 18;4(1). doi: 10.3390/bioengineering4010001. PMID: 28952482; PMCID: PMC5590441.
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Bioengineering (Basel). 2017 Jan 18;4(1). doi: 10.3390/bioengineering4010001.

Polysaccharide Fabrication Platforms and Biocompatibility Assessment as Candidate Wound Dressing Materials.

Bioengineering (Basel, Switzerland)

Donald C Aduba, Hu Yang

Affiliations

  1. Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA. [email protected].
  2. Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA. [email protected].
  3. Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA 23298, USA. [email protected].
  4. Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA. [email protected].

PMID: 28952482 PMCID: PMC5590441 DOI: 10.3390/bioengineering4010001

Abstract

Wound dressings are critical for wound care because they provide a physical barrier between the injury site and outside environment, preventing further damage or infection. Wound dressings also manage and even encourage the wound healing process for proper recovery. Polysaccharide biopolymers are slowly becoming popular as modern wound dressings materials because they are naturally derived, highly abundant, inexpensive, absorbent, non-toxic and non-immunogenic. Polysaccharide biopolymers have also been processed into biomimetic platforms that offer a bioactive component in wound dressings that aid the healing process. This review primarily focuses on the fabrication and biocompatibility assessment of polysaccharide materials. Specifically, fabrication platforms such as electrospun fibers and hydrogels, their fabrication considerations and popular polysaccharides such as chitosan, alginate, and hyaluronic acid among emerging options such as arabinoxylan are discussed. A survey of biocompatibility and bioactive molecule release studies, leveraging polysaccharide's naturally derived properties, is highlighted in the text, while challenges and future directions for wound dressing development using emerging fabrication techniques such as 3D bioprinting are outlined in the conclusion. This paper aims to encourage further investigation and open up new, disruptive avenues for polysaccharides in wound dressing material development.

Keywords: foam; hydrogel; nanofiber; polysaccharide; skin; wound dressing; wound healing; wound management

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