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Murphy SR, Wang L, Wang Z, et al. β-Adrenergic Inhibition Prevents Action Potential and Calcium Handling Changes during Regional Myocardial Ischemia. Front Physiol. 2017;8:630doi: 10.3389/fphys.2017.00630.
Murphy, S. R., Wang, L., Wang, Z., Domondon, P., Lang, D., Habecker, B. A., Myles, R. C., & Ripplinger, C. M. (2017). β-Adrenergic Inhibition Prevents Action Potential and Calcium Handling Changes during Regional Myocardial Ischemia. Frontiers in physiology, 8630. https://doi.org/10.3389/fphys.2017.00630
Murphy, Shannon R, et al. "β-Adrenergic Inhibition Prevents Action Potential and Calcium Handling Changes during Regional Myocardial Ischemia." Frontiers in physiology vol. 8 (2017): 630. doi: https://doi.org/10.3389/fphys.2017.00630
Murphy SR, Wang L, Wang Z, Domondon P, Lang D, Habecker BA, Myles RC, Ripplinger CM. β-Adrenergic Inhibition Prevents Action Potential and Calcium Handling Changes during Regional Myocardial Ischemia. Front Physiol. 2017 Aug 28;8:630. doi: 10.3389/fphys.2017.00630. eCollection 2017. PMID: 28894423; PMCID: PMC5581400.
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Front Physiol. 2017 Aug 28;8:630. doi: 10.3389/fphys.2017.00630. eCollection 2017.

β-Adrenergic Inhibition Prevents Action Potential and Calcium Handling Changes during Regional Myocardial Ischemia.

Frontiers in physiology

Shannon R Murphy, Lianguo Wang, Zhen Wang, Philip Domondon, Di Lang, Beth A Habecker, Rachel C Myles, Crystal M Ripplinger

Affiliations

  1. Department of Pharmacology, University of California, DavisDavis, CA, United States.
  2. Department of Biomedical Engineering, University of California, DavisDavis, CA, United States.
  3. Department of Physiology and Pharmacology, Oregon Health & Science UniversityPortland, OR, United States.
  4. Institute of Cardiovascular and Medical Sciences, University of GlasgowGlasgow, United Kingdom.

PMID: 28894423 PMCID: PMC5581400 DOI: 10.3389/fphys.2017.00630

Abstract

β-adrenergic receptor (β-AR) blockers may be administered during acute myocardial infarction (MI), as they reduce energy demand through negative chronotropic and inotropic effects and prevent ischemia-induced arrhythmogenesis. However, the direct effects of β-AR blockers on ventricular electrophysiology and intracellular Ca

Keywords: arrhythmia; beta blocker; calcium; ischemia; sarcoplasmic reticulum

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