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Tuure L, Hämäläinen M, Whittle BJ, et al. Microsomal Prostaglandin E Synthase-1 Expression in Inflammatory Conditions Is Downregulated by Dexamethasone: Seminal Role of the Regulatory Phosphatase MKP-1. Front Pharmacol. 2017;8:646doi: 10.3389/fphar.2017.00646.
Tuure, L., Hämäläinen, M., Whittle, B. J., & Moilanen, E. (2017). Microsomal Prostaglandin E Synthase-1 Expression in Inflammatory Conditions Is Downregulated by Dexamethasone: Seminal Role of the Regulatory Phosphatase MKP-1. Frontiers in pharmacology, 8646. https://doi.org/10.3389/fphar.2017.00646
Tuure, Lauri, et al. "Microsomal Prostaglandin E Synthase-1 Expression in Inflammatory Conditions Is Downregulated by Dexamethasone: Seminal Role of the Regulatory Phosphatase MKP-1." Frontiers in pharmacology vol. 8 (2017): 646. doi: https://doi.org/10.3389/fphar.2017.00646
Tuure L, Hämäläinen M, Whittle BJ, Moilanen E. Microsomal Prostaglandin E Synthase-1 Expression in Inflammatory Conditions Is Downregulated by Dexamethasone: Seminal Role of the Regulatory Phosphatase MKP-1. Front Pharmacol. 2017 Sep 21;8:646. doi: 10.3389/fphar.2017.00646. eCollection 2017. PMID: 28983247; PMCID: PMC5613146.
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Front Pharmacol. 2017 Sep 21;8:646. doi: 10.3389/fphar.2017.00646. eCollection 2017.

Microsomal Prostaglandin E Synthase-1 Expression in Inflammatory Conditions Is Downregulated by Dexamethasone: Seminal Role of the Regulatory Phosphatase MKP-1.

Frontiers in pharmacology

Lauri Tuure, Mari Hämäläinen, Brendan J Whittle, Eeva Moilanen

Affiliations

  1. The Immunopharmacology Research Group, Faculty of Medicine and Life Sciences, University of Tampere, Tampere University HospitalTampere, Finland.
  2. William Harvey Research Institute, Barts and the London School of MedicineLondon, United Kingdom.

PMID: 28983247 PMCID: PMC5613146 DOI: 10.3389/fphar.2017.00646

Abstract

Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme situated downstream of cyclo-oxygenase-2, promoting the excessive PGE

Keywords: JNK; MAP kinases; MKP-1; mPGES-1; prostaglandins

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