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SAGE Open Med. 2017 Aug 31;5:2050312117727999. doi: 10.1177/2050312117727999. eCollection 2017.

Comparison of claims data on hospitalization rates and repeat procedures in patients receiving a bowel preparation prior to colonoscopy.

SAGE open medicine

Lisa E Young, Naomi C Sacks, Philip L Cyr, Abhishek Sharma, David N Dahdal

Affiliations

  1. Ferring Pharmaceuticals Inc., Parsippany, NJ, USA.
  2. Precision Health Economics, Boston, MA, USA.
  3. School of Medicine, Tufts University, Boston, MA, USA.
  4. University of North Carolina at Charlotte, Charlotte, NC, USA.
  5. Department of Global Health and Center for Global Health & Development, School of Public Health, Boston University, Boston, MA, USA.

PMID: 28894587 PMCID: PMC5582656 DOI: 10.1177/2050312117727999

Abstract

OBJECTIVES: To evaluate outcomes of colorectal screening using sodium picosulfate and magnesium citrate compared with other prescription bowel-preparation agents. Primary endpoints were rates of procedure-associated hospitalizations, diagnosis at hospitalization, and rates of early repeat screenings.

METHODS: This retrospective cohort study identified patients using the Truven Health Analytics MarketScan databases, which contain fully adjudicated, de-identified, medical- and prescription-drug claims, as well as demographic and enrollment information for individuals with commercial, Medicaid, and Medicare supplemental insurance coverage. Patients who had a colonoscopy or sigmoidoscopy over a 3-year period were identified using

RESULTS: A total of 566,628 procedures were identified in the MarketScan databases and included in the study. Sodium picosulfate and magnesium citrate performed well in terms of safety outcomes, with no hospitalizations due to diagnosis of hyponatremia, dehydration, or other fluid disorders in the 10 days after procedure. Early repeat rates among sodium picosulfate and magnesium citrate patients were comparable with rates observed for all other cleansing agents.

CONCLUSION: Outcomes of colorectal screening using sodium picosulfate and magnesium citrate were not significantly different compared with other prescription bowel-preparation agents.

Keywords: Bowel preparation; Prepopik; colonoscopy preparation; colorectal cancer screening; health economics; health insurance; outcomes research; sodium picosulfate and magnesium citrate

Conflict of interest statement

Declaration of conflicting interests: L.E.Y. and D.N.D. are employees of Ferring Pharmaceuticals Inc. N.C.S., P.L.C., and A.S. are employees of Precision Health Economics.

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