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Salcido-Ochoa F, Hue SS, Haase D, et al. Analysis of T Cell Subsets in Adult Primary/Idiopathic Minimal Change Disease: A Pilot Study. Int J Nephrol. 2017;2017:3095425doi: 10.1155/2017/3095425.
Salcido-Ochoa, F., Hue, S. S., Haase, D., Choo, J. C. J., Yusof, N., Li, R. L., Allen, J. C., Iqbal, J., Loh, A. H. L., & Rotzschke, O. (2017). Analysis of T Cell Subsets in Adult Primary/Idiopathic Minimal Change Disease: A Pilot Study. International journal of nephrology, 20173095425. https://doi.org/10.1155/2017/3095425
Salcido-Ochoa, Francisco, et al. "Analysis of T Cell Subsets in Adult Primary/Idiopathic Minimal Change Disease: A Pilot Study." International journal of nephrology vol. 2017 (2017): 3095425. doi: https://doi.org/10.1155/2017/3095425
Salcido-Ochoa F, Hue SS, Haase D, Choo JCJ, Yusof N, Li RL, Allen JC, Iqbal J, Loh AHL, Rotzschke O. Analysis of T Cell Subsets in Adult Primary/Idiopathic Minimal Change Disease: A Pilot Study. Int J Nephrol. 2017;2017:3095425. doi: 10.1155/2017/3095425. Epub 2017 Aug 15. PMID: 28894608; PMCID: PMC5574215.
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Int J Nephrol. 2017;2017:3095425. doi: 10.1155/2017/3095425. Epub 2017 Aug 15.

Analysis of T Cell Subsets in Adult Primary/Idiopathic Minimal Change Disease: A Pilot Study.

International journal of nephrology

Francisco Salcido-Ochoa, Susan Swee-Shan Hue, Doreen Haase, Jason Chon Jun Choo, Nurhashikin Yusof, Reiko Lixiang Li, John Carson Allen, Jabed Iqbal, Alwin Hwai Liang Loh, Olaf Rotzschke

Affiliations

  1. Tregs and HLA Research Force, Singapore General Hospital, The Academia, 20 College Road, Singapore 169856.
  2. Renal Medicine Department, Singapore General Hospital, The Academia, 20 College Road, Singapore 169856.
  3. Department of Pathology, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074.
  4. Kompetenznetz Vorhofflimmern e.V. (AFNET), Münster, Germany.
  5. Singapore Immunology Network (SIGN), Agency for Science, Technology and Research (ASTAR), Biopolis, Singapore.
  6. Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229899.
  7. Centre for Quantitative Medicine, Duke-NUS Graduate Medical School, The Academia, 20 College Road, Singapore 169856.
  8. Department of Pathology, Singapore General Hospital, The Academia, 20 College Road, Singapore 169856.

PMID: 28894608 PMCID: PMC5574215 DOI: 10.1155/2017/3095425

Abstract

AIM: To characterise infiltrating T cells in kidneys and circulating lymphocyte subsets of adult patients with primary/idiopathic minimal change disease.

METHODS: In a cohort of 9 adult patients with primary/idiopathic minimal change recruited consecutively at disease onset, we characterized (1) infiltrating immune cells in the kidneys using immunohistochemistry and (2) circulating lymphocyte subsets using flow cytometry. As an exploratory analysis, association of the numbers and percentages of both kidney-infiltrating immune cells and the circulating lymphocyte subsets with kidney outcomes including deterioration of kidney function and proteinuria, as well as time to complete clinical remission up to 48 months of follow-up, was investigated.

RESULTS: In the recruited patients with primary/idiopathic minimal change disease, we observed (a) a dominance of infiltrating T helper 17 cells and cytotoxic cells, comprising cytotoxic T cells and natural killer cells, over Foxp3+ Treg cells in the renal interstitium; (b) an increase in the circulating total CD8+ T cells in peripheral blood; and (c) an association of some of these parameters with kidney function and proteinuria.

CONCLUSIONS: In primary/idiopathic minimal change disease, a relative numerical dominance of effector over regulatory T cells can be observed in kidney tissue and peripheral blood. However, larger confirmatory studies are necessary.

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